Brief report: The influence of childhood trauma on the effects of delta-9-tetrahydrocannabinol in persons with opioid use disorder.

BACKGROUND AND

OBJECTIVES

Childhood trauma (CT) increases addiction vulnerability. We examined CT's impact on delta-9-tetrahydrocannabinol (THC) effects.

METHODS

This is a post-hoc analysis of a randomized, placebo-controlled, crossover trial investigating the effects of oral THC (10, 20 mg) among 25 persons receiving methadone for opioid use disorder (OUD).

RESULTS

Greater CT was associated with lower aversive effects from higher THC doses (20 mg) (p = .006).

DISCUSSION AND

CONCLUSIONS

CT may reduce the subjective aversive effects of THC, potentially leading to greater cannabis use in individuals with OUD.

SCIENTIFIC SIGNIFICANCE: These findings offer insights into THC's risks versus benefits in OUD subgroups and emphasize assessing CT in OUD treatment and research.