Pediatric blood & cancer · 2026
Treatment Patterns and Outcomes of Pediatric Chronic Myeloid Leukemia in a Brazilian Multicenter Cohort.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод в очереди
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da Silva Maria Eduarda Mayer, Dos Santos Vitória Flores, Pecoits Rodrigo Pirih, Rechenmacher Ciliana, Corrêa Kizy da Costa, Marques Rebeca Ferreira, de Sousa Ana Virginia Lopes, de Jesus Marques Salles Terezinha, Lins Mecneide Mendes, Monteiro Priscila, Moura Patricia Gomes, Moreira Larissa Bueno Polis, Rosa Vanuza Maria, de Carvalho Filho Neviçolino Pereira, Epelman Sidnei, Daudt Liane Esteves, Morales Daniela Dias, Kersting Nathalia, Michalowski Mariana Bohns
Аннотация
This multicenter retrospective cohort study evaluated the treatment patterns and outcomes of 79 children and adolescents with chronic myeloid leukemia who were treated at eight Brazilian centers from 2000 to 2025. Most patients were diagnosed in chronic phase (90.7%) and received frontline imatinib (89.9). At 12 months, optimal molecular response was achieved in 86.5% of evaluable patients (45/52). Survival outcomes were favorable, with overall and event-free survival of 93.7% (74/79) and 72.1% (57/79), respectively. Notably, outcomes were comparable to international pediatric cohorts despite heterogeneous access to molecular monitoring and second-generation tyrosine kinase inhibitors.