Dermatitis : contact, atopic, occupational, drug · 2025
The Changing Spectrum of Pediatric Allergic Contact Dermatitis: A Prospective Multicentric Study in Spain.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод в очереди
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Planella-Fontanillas Nidia, Pesqué David, Borrego Leopoldo, Zaragoza Ninet Violeta, Miquel Miquel Javier, Sanz-Sánchez Tatiana, Silvestre Salvador Juan Francisco, Carrascosa Carrillo José Manuel, Munera-Campos Mónica, Córdoba Guijarro Susana, González Pérez Ricardo, Serra Baldrich Esther, Gatica Ortega María Elena, Mercader-García Pedro, Ruiz Gonzales Inmaculada, Linares Navarro Rubén, Ortiz de Frutos Francisco Javier, Tous Romero Fátima, Rodríguez Serna Mercedes, Pastor Nieto María Antonia, Sánchez Pérez Javier, Sánchez Gilo Araceli, Melé-Ninot Gemma, Barrabés-Torrella Cristina, Gómez de la Fuente Enrique, Sánchez-Pedreño Guillén Paloma, Lova Navarro Miguel, Navarro Triviño Francisco, Pereyra Rodríguez José Juan, Pujol Ramon M, Ángel Descalzo Miguel, García Doval Ignacio, Giménez-Arnau Ana M
Аннотация
Background: Allergic contact dermatitis (ACD) is increasingly common in children, with age-related variations suggesting changing exposure patterns.Objective: Updating clinical and epidemiological characteristics, sensitization frequency, and relevance of positive patch tests in pediatric patients.Methods: This prospective multicenter study analyzed data from the Spanish Contact Dermatitis Research Group registry (REIDAC) for patients aged 0-16 years, stratified into 2 groups: 0-5 and 6-16 years. Participants were patch tested with the GEIDAC baseline and extended series from January 2019 to December 2023.Results: Patch tests were performed on 508 children, of whom 179 (35.2%) were sensitized. Among children aged 0-5 years (n = 41), 10 (24.4%) had positive patch tests, with lesions predominantly affecting the face (51.2%), hands (17.0%), and legs (4.9%). Atopic dermatitis (AD) was present in 36.6%, with linalool and limonene hydroperoxides as top sensitizers. In the 6-16 years group (n = 467), 169 patients (36.2%) were sensitized. AD was present in 45.0%, with lesions involving the face (24.0%), hands (23%), and legs (7.0%). Top allergens were linalool hydroperoxide and methylisothiazolinone.Conclusions: High sensitization proportions in both age groups highlight the importance of patch testing. Hydroperoxides of linalool and limonene are emerging as key sensitizers. Age-specific considerations may improve pediatric ACD management.