Journal of affective disorders · 2025
Comorbid clinical and biomarker outcomes in patients with obsessive-compulsive disorder: An umbrella review and evidence map.
СтатьяСистематический обзорНазвание и аннотация: Перевод в очереди
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Joo Hajung, Kong Jaehyun, Hong Seohyun, Jo Yeona, Son Yejun, Lee Sooji, Yeo Dongjin, Lee Kyeongmin, Lee Hayeon, Woo Ho Geol, Boyer Laurent, Fond Guillaume, Yon Dong Keon
Аннотация
BACKGROUND: Obsessive-compulsive disorder (OCD) is a chronic psychiatric condition with diverse comorbidities, yet outcome research remains limited. Thus, we aimed to systematically review existing meta-analyses of OCD-associated comorbid outcomes and assess the strength of evidence.
METHODS: We conducted an umbrella review of meta-analyses, searching PubMed/MEDLINE, Embase, CINAHL, and Google Scholar up to July 7, 2025. Although we intended to include all studies related to OCD-associated comorbid outcomes, only observational studies were available. Effect sizes were recalculated using random-effects models, and all estimates were converted to equivalent standardized mean differences (eSMD) with 95 % confidence intervals (CIs). The methodological quality of the included reviews was assessed using the AMSTAR 2 tool, and the class of evidence (CE) for each association was graded according to predefined criteria (Class I-IV).
RESULTS: We identified 17 meta-analyses that included 373 primary studies, covering 52 outcomes in 156,161 participants across 40 countries. Patients with OCD were associated with autistic traits outcomes, including restricted and repetitive behaviors (eSMD, 1.66 [95 % CI, 1.25-2.07]; CE = IV), and total autism-spectrum quotient score (1.40 [1.06-1.81]; CE = IV). OCD also showed associations of varying strength with several other outcomes, including suicidal attempt (0.64 [0.47-0.81]; CE = II) and toxoplasmosis infection (0.37 [0.15-0.59]; CE = III). Furthermore, quality of life was decreased across multiple domains in individuals with OCD (emotional, -1.47 [-1.96 to -0.98]; CE = II; global, -0.79 [-1.02 to -0.55]; CE = II; work/social, -1.21 [-1.72 to -0.69]; CE = III).
CONCLUSION: Our study highlights the comprehensive impact of OCD, indicating associations with autism, suicidality, social-cognitive deficits, impaired quality of life, and neurobiological markers.
STUDY REGISTRATION: PROSPERO CRD420251124380.
METHODS: We conducted an umbrella review of meta-analyses, searching PubMed/MEDLINE, Embase, CINAHL, and Google Scholar up to July 7, 2025. Although we intended to include all studies related to OCD-associated comorbid outcomes, only observational studies were available. Effect sizes were recalculated using random-effects models, and all estimates were converted to equivalent standardized mean differences (eSMD) with 95 % confidence intervals (CIs). The methodological quality of the included reviews was assessed using the AMSTAR 2 tool, and the class of evidence (CE) for each association was graded according to predefined criteria (Class I-IV).
RESULTS: We identified 17 meta-analyses that included 373 primary studies, covering 52 outcomes in 156,161 participants across 40 countries. Patients with OCD were associated with autistic traits outcomes, including restricted and repetitive behaviors (eSMD, 1.66 [95 % CI, 1.25-2.07]; CE = IV), and total autism-spectrum quotient score (1.40 [1.06-1.81]; CE = IV). OCD also showed associations of varying strength with several other outcomes, including suicidal attempt (0.64 [0.47-0.81]; CE = II) and toxoplasmosis infection (0.37 [0.15-0.59]; CE = III). Furthermore, quality of life was decreased across multiple domains in individuals with OCD (emotional, -1.47 [-1.96 to -0.98]; CE = II; global, -0.79 [-1.02 to -0.55]; CE = II; work/social, -1.21 [-1.72 to -0.69]; CE = III).
CONCLUSION: Our study highlights the comprehensive impact of OCD, indicating associations with autism, suicidality, social-cognitive deficits, impaired quality of life, and neurobiological markers.
STUDY REGISTRATION: PROSPERO CRD420251124380.