Journal of affective disorders · 2015
Prevalence of cavum vergae in psychosis and mood spectrum disorders.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Landin-Romero Ramón, Sarró Salvador, Fernández-Corcuera Paloma, Moro Noemí, Manuel Goikolea Jose, Isabel Carrión María, Pomarol-Clotet Edith, Amann Benedikt L, Radua Joaquim
Аннотация
BACKGROUND: Midline brain abnormalities might increase susceptibility to both first-episode and chronic mental disorder. Evidence of cavum vergae (CV) abnormality in mental disorders is scarce.
METHODS: The presence of CV was assessed by a researcher blind to clinical information in a cross-disorder sample of 639 patients with mood and psychotic disorders and in 223 healthy controls. Homogeneous magnetic resonance imaging methods of acquisition and assessment were applied.
RESULTS: Seven out of 639 patients with mood or psychotic disorders were detected with CV which corresponds to a prevalence of 1.1%. There were no concurrent cases of CV in the healthy control group. Identified cases which are briefly described were diagnosed from bipolar I disorder (n=2), delusional disorder (n=1), brief psychotic disorder (n=1) and schizoaffective disorder (n=3). Patients with CV had descriptively lower current IQ, executive functioning and memory scores in relation to patients without CV but this was not statistically significant.
LIMITATIONS: Effects of medication and lack of statistical power of the CV patient group.
CONCLUSIONS: Midline brain abnormalities, such as CV, might represent an unspecific risk factor for the development of severe mental disorders.
METHODS: The presence of CV was assessed by a researcher blind to clinical information in a cross-disorder sample of 639 patients with mood and psychotic disorders and in 223 healthy controls. Homogeneous magnetic resonance imaging methods of acquisition and assessment were applied.
RESULTS: Seven out of 639 patients with mood or psychotic disorders were detected with CV which corresponds to a prevalence of 1.1%. There were no concurrent cases of CV in the healthy control group. Identified cases which are briefly described were diagnosed from bipolar I disorder (n=2), delusional disorder (n=1), brief psychotic disorder (n=1) and schizoaffective disorder (n=3). Patients with CV had descriptively lower current IQ, executive functioning and memory scores in relation to patients without CV but this was not statistically significant.
LIMITATIONS: Effects of medication and lack of statistical power of the CV patient group.
CONCLUSIONS: Midline brain abnormalities, such as CV, might represent an unspecific risk factor for the development of severe mental disorders.