Epilepsy & behavior : E&B · 2025
Association between psychiatric disorders and the clinical semiology of functional seizures in patients with and without comorbid epilepsy.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Maslowski Anja, Rosenow Felix, Strzelczyk Adam, Willems Laurent M
Аннотация
OBJECTIVE: To investigate the association between the semiology of functional seizures (FS) and comorbid psychiatric disorders in patients with and without epilepsy.
METHODS: Adult patients diagnosed with FS during video-electroencephalography-monitoring at the Epilepsy Centre Frankfurt Rhine-Main between 2016 and 2024 were retrospectively identified. Functional seizures were categorized into six classes based on the classification proposed by Wadwekar. Statistical analysis was performed using Kruskal-Wallis test and multivariate ordinal regression analysis (MORA).
RESULTS: A total of 2,784 patients were screened, and 603 FS were analysed from 216 patients (75.0 % female, mean age 36.7 years, range 18.0-79.0 years). The most common form (30.5 %, n = 244) were non-motor FS of class VI, followed by class IV hyperkinetic (27.2 %, n = 164), class II paucikinetic (21.9 %, n = 132), class III pseudosyncope (5.0 %, n = 30), class I dystonic (3.2 %, n = 19), and class V axial dystonic (2.2 % n = 13). Univariate analysis revealed a significant association between class II FS and borderline personality disorder (BPD, p = 0.036), class III FS and post-traumatic stress disorder (PTSD, p = 0.041), and class IV FS with a diagnosis of depression (p = 0.014). Multivariate analysis revealed a significant association between class II FS and comorbid anxiety and panic disorder (p = 0.037), as well as with BPD (p = 0.010); further associations were found for class III FS with PTSD (p = 0.015) and with epilepsy (p = 0.015), and between class VI FS and living alone (p = 0.047). In patients with comorbid epilepsy, class II FS were significantly more frequent (p = 0.047).
SIGNIFICANCE: The semiology of FS seems to be associated with psychiatric comorbidities which may improve the understanding of individual manifestations.
METHODS: Adult patients diagnosed with FS during video-electroencephalography-monitoring at the Epilepsy Centre Frankfurt Rhine-Main between 2016 and 2024 were retrospectively identified. Functional seizures were categorized into six classes based on the classification proposed by Wadwekar. Statistical analysis was performed using Kruskal-Wallis test and multivariate ordinal regression analysis (MORA).
RESULTS: A total of 2,784 patients were screened, and 603 FS were analysed from 216 patients (75.0 % female, mean age 36.7 years, range 18.0-79.0 years). The most common form (30.5 %, n = 244) were non-motor FS of class VI, followed by class IV hyperkinetic (27.2 %, n = 164), class II paucikinetic (21.9 %, n = 132), class III pseudosyncope (5.0 %, n = 30), class I dystonic (3.2 %, n = 19), and class V axial dystonic (2.2 % n = 13). Univariate analysis revealed a significant association between class II FS and borderline personality disorder (BPD, p = 0.036), class III FS and post-traumatic stress disorder (PTSD, p = 0.041), and class IV FS with a diagnosis of depression (p = 0.014). Multivariate analysis revealed a significant association between class II FS and comorbid anxiety and panic disorder (p = 0.037), as well as with BPD (p = 0.010); further associations were found for class III FS with PTSD (p = 0.015) and with epilepsy (p = 0.015), and between class VI FS and living alone (p = 0.047). In patients with comorbid epilepsy, class II FS were significantly more frequent (p = 0.047).
SIGNIFICANCE: The semiology of FS seems to be associated with psychiatric comorbidities which may improve the understanding of individual manifestations.