Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2026
Survival and prognostic factors of parotid malignancies in Northern Italy: a multicentric study.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод в очереди
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Molinari Giulia, Cantaffa Carla, Spina Federica, Mattioli Francesco, Marchioni Daniele, Maccarrone Francesco, Lo Manto Alfredo, Vaccari Caterina, Russo Paolo, Ghidini Angelo, Murri Domenico, Del Giovane Cinzia, Chiarini Luigi, Di Bartolomeo Mattia, Nocini Pier Francesco, Nocini Riccardo, Carosi Carlo, Botti Cecilia, Molteni Gabriele, Presutti Livio, Alicandri-Ciufelli Matteo
Аннотация
OBJECTIVE: The aim of this study is to report oncological outcomes of a multicentric cohort of surgically-treated parotid gland malignancies (PGMs) and compare them with other Italian Institutions.
METHODS: This is a retrospective multicentric study on surgically-treated patients with PGM. Overall survival (OS), disease-free survival (DFS) and disease-specific survival (DSS) at 5 years were calculated. The Cox proportional hazard model was used for uni- and multivariate analyses. A qualitative review of the Italian literature was performed.
RESULTS: One-hundred and six patients were included. Negative prognostic factors included deep lobe involvement, size > 4 cm, advanced stage, margin status, histological grade, nodal involvement and extranodal disease. Parotidectomy extent did not influence DSS or DFS for T1-T2 superficial tumours. The occult lymph node metastasis rate was 30.8%. Neither elective neck dissection (END) nor elective neck irradiation (ENI) influenced DFS or DSS.
CONCLUSIONS: Deep lobe removal in pT1-T2 superficial tumours may not always be necessary. END and ENI did not show a significant impact on prognosis, despite a high incidence of occult nodal metastasis. Further studies are needed to fully evaluate the impact of these therapeutic options in subgroups of patients with PGMs.
METHODS: This is a retrospective multicentric study on surgically-treated patients with PGM. Overall survival (OS), disease-free survival (DFS) and disease-specific survival (DSS) at 5 years were calculated. The Cox proportional hazard model was used for uni- and multivariate analyses. A qualitative review of the Italian literature was performed.
RESULTS: One-hundred and six patients were included. Negative prognostic factors included deep lobe involvement, size > 4 cm, advanced stage, margin status, histological grade, nodal involvement and extranodal disease. Parotidectomy extent did not influence DSS or DFS for T1-T2 superficial tumours. The occult lymph node metastasis rate was 30.8%. Neither elective neck dissection (END) nor elective neck irradiation (ENI) influenced DFS or DSS.
CONCLUSIONS: Deep lobe removal in pT1-T2 superficial tumours may not always be necessary. END and ENI did not show a significant impact on prognosis, despite a high incidence of occult nodal metastasis. Further studies are needed to fully evaluate the impact of these therapeutic options in subgroups of patients with PGMs.