The Indian journal of tuberculosis · 2025
An observational study on the utilization of cartridge based nucleic acid amplification test (CBNAAT) in diagnostic evaluation of chronic ulcer with respect to histopathological examination.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Lakhotiya Priyanka, Singh Parihar Ummed, Agarwal Kalpana, Kuldeep Rajveer, Dixit Ramakant, Rawal Pramod, Raj Hans
Аннотация
INTRODUCTION: An ulcer is defined as a discontinuity of either skin or mucous membrane due to loss of blood supply. Chronic non healing ulcers may required 6 weeks or more to heal after coventional therapies.
OBJECTIVE: To compare the diagnostic evaluation of chronic ulcer by CBNAAT and histopathology examination.
METHODS: Prospective Observational study conducted on 100 cases of chronic non-healing ulcer by consecutive sampling attended to outdoor and indoor patient department of surgery for one year period (July 2021-august 2022) at JLN Hospital, Ajmer.
RESULTS: Mean age was 44.73 ± 16.34 years with age range of 12-80 years. Male: Female ratio was found to be 1.5:1. Out of 100 cases, tuberculosis was diagnosed in 14% cases by CBNAAT and in 13% cases by histopathological examination. Out of 14 CBNAAT positive cases, 28.57% cases were found to be rifampicin resistant. For CBNAAT, sensitivity is 64.28% and specificity is 95.34%. So Positive predictive value is 69.23% and negative predictive value is 94.25%.
CONCLUSION: In chronic wounds, CBNAAT had high specificity and low sensitivity, making it a diagnostic tool.
OBJECTIVE: To compare the diagnostic evaluation of chronic ulcer by CBNAAT and histopathology examination.
METHODS: Prospective Observational study conducted on 100 cases of chronic non-healing ulcer by consecutive sampling attended to outdoor and indoor patient department of surgery for one year period (July 2021-august 2022) at JLN Hospital, Ajmer.
RESULTS: Mean age was 44.73 ± 16.34 years with age range of 12-80 years. Male: Female ratio was found to be 1.5:1. Out of 100 cases, tuberculosis was diagnosed in 14% cases by CBNAAT and in 13% cases by histopathological examination. Out of 14 CBNAAT positive cases, 28.57% cases were found to be rifampicin resistant. For CBNAAT, sensitivity is 64.28% and specificity is 95.34%. So Positive predictive value is 69.23% and negative predictive value is 94.25%.
CONCLUSION: In chronic wounds, CBNAAT had high specificity and low sensitivity, making it a diagnostic tool.