Science advances · 2026
Dendritic shaft constrictions shape synaptic integration in neurons.
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Kelly Tony, Döngi Michael, Rodriguez-Gatica Juan Eduardo, Ofer Netanel, Wert-Carvajal Carlos, Cissewski Niclas, Barboni Michela, Bethge Philipp, Godale Christin M, Yaser Sarah, Herde Michel K, Tillmann Jens, Peter Sabrina Ingrid, Dupraz Sebastian, Koch Henner, Stein Valentin, Bradke Frank, Danzer Steve C, Tchumatchenko Tatjana, Schwarz Martin K, Kubitscheck Ulrich, Nägerl U Valentin, Beck Heinz
Аннотация
For nearly 150 years, textbooks have described dendritic morphology as optimized for efficient synaptic voltage transfer from spines to the soma, implemented as a tubular design respecting Rall's 3/2 rule for impedance matching at branch points. Here, we reveal that this view is an oversimplification. Using multiple high-resolution imaging techniques, we demonstrate that dendrites in cortical and hippocampal neurons exhibit nanoscale constrictions, termed dendritic shaft constrictions (DSCs), with diameters ranging from ∼100 to 500 nanometers in mice. We also identified DSCs in human hippocampal and cortical neurons. We provide theoretical and experimental lines of evidence that these constrictions effectively partition the dendrite into distinct electrical compartments, shaping dendritic integration of synaptic potentials.