Clinical oncology (Royal College of Radiologists (Great Britain)) · 2026
Outcomes Following Definitive Chemoradiation in Locally Advanced Laryngeal and Hypopharyngeal Cancers: Experience From a Tertiary Care Centre.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Shah S K, Sharma C, Rathee N, Maity S, Mallick I, Chatterjee S
Аннотация
AIMS: Laryngeal conservation in advanced disease is possible with chemo-radiation (CTRT); however, it is at the expense of significant toxicity. There is sparse data from the Indian subcontinent addressing the same.
MATERIALS AND METHODS: A retrospective cohort study of Stage III-IVa/b patients treated between May 2011 and April 2022. We assessed survival outcomes, organ preservation rates, and toxicities.
RESULTS: 300 patients, with a median age of 63 years (57;69), were identified. Median follow-up was 4.1 years (3.5; 4.4). Dysphagia was the most common grade 3 toxicity (119; 40%). The 5-year overall survival (OS) was 61% (55%; 69%). Sitewise, laryngeal cancers (64% (55%; 74%)) fared better than hypopharyngeal cancers (55% (45%; 67%)) with respect to 5-year OS. The larynx preservation rate was 84% (79%; 90%) at 5 years.
CONCLUSION: Functional laryngeal preservation is achievable in locally advanced laryngeal and hypopharyngeal cancers with definitive CTRT. Outcomes aligned with established and published data.
MATERIALS AND METHODS: A retrospective cohort study of Stage III-IVa/b patients treated between May 2011 and April 2022. We assessed survival outcomes, organ preservation rates, and toxicities.
RESULTS: 300 patients, with a median age of 63 years (57;69), were identified. Median follow-up was 4.1 years (3.5; 4.4). Dysphagia was the most common grade 3 toxicity (119; 40%). The 5-year overall survival (OS) was 61% (55%; 69%). Sitewise, laryngeal cancers (64% (55%; 74%)) fared better than hypopharyngeal cancers (55% (45%; 67%)) with respect to 5-year OS. The larynx preservation rate was 84% (79%; 90%) at 5 years.
CONCLUSION: Functional laryngeal preservation is achievable in locally advanced laryngeal and hypopharyngeal cancers with definitive CTRT. Outcomes aligned with established and published data.