Orphanet journal of rare diseases · 2025
Aspiration, respiratory complications, and associated healthcare resource utilization among individuals with Rett syndrome.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Rashid Nazia, Darer Jonathan D, Ruetsch Charles, Yang Xiaoyun
Аннотация
BACKGROUND: Individuals with Rett syndrome (RTT) are at high risk for aspiration and also experience high rates of lower respiratory tract infections (LRTI) and respiratory failure (RF).
METHODS: A retrospective comparative cohort analysis was performed among 89 individuals with RTT with and without evidence of aspiration, using EHR structured and abstracted clinical notes data. Individuals with known or suspected aspiration (per clinical documentation) (cases) were compared to controls on aspiration risk factors, RF, LRTI, and hospitalization.
RESULTS: Of eligible individuals, 25 (28.1%) were aspiration cases. The cumulative rate of RF among RTT individuals with and without aspiration was 60.0% and 6.3%, respectively. Aspiration cases were more likely to have risk factors compared to controls during the 6-month baseline including epilepsy (54.5% vs. 4.5%), dysphagia (40.9% vs. 0%), GERD (31.8% vs. 0.0%), scoliosis (31.8% vs. 4.5%), and vomiting (18.2% vs. 0.0%). Aspiration cases were more likely to have LRTI (50% vs. 5.0%) and ≥ 1 inpatient admissions than non-aspiration controls (75.0% vs. 35.0%) (all p < 0.05).
CONCLUSIONS: Individuals with RTT with known or suspected aspiration are at increased risk of LRTI, RF, and inpatient admissions. Providers should monitor aspiration and institute preventative measures among individuals with aspiration risk factors even in the absence of aspiration symptoms.
METHODS: A retrospective comparative cohort analysis was performed among 89 individuals with RTT with and without evidence of aspiration, using EHR structured and abstracted clinical notes data. Individuals with known or suspected aspiration (per clinical documentation) (cases) were compared to controls on aspiration risk factors, RF, LRTI, and hospitalization.
RESULTS: Of eligible individuals, 25 (28.1%) were aspiration cases. The cumulative rate of RF among RTT individuals with and without aspiration was 60.0% and 6.3%, respectively. Aspiration cases were more likely to have risk factors compared to controls during the 6-month baseline including epilepsy (54.5% vs. 4.5%), dysphagia (40.9% vs. 0%), GERD (31.8% vs. 0.0%), scoliosis (31.8% vs. 4.5%), and vomiting (18.2% vs. 0.0%). Aspiration cases were more likely to have LRTI (50% vs. 5.0%) and ≥ 1 inpatient admissions than non-aspiration controls (75.0% vs. 35.0%) (all p < 0.05).
CONCLUSIONS: Individuals with RTT with known or suspected aspiration are at increased risk of LRTI, RF, and inpatient admissions. Providers should monitor aspiration and institute preventative measures among individuals with aspiration risk factors even in the absence of aspiration symptoms.