Nature microbiology · 2024
Multinational epidemiological analysis of oral human papillomavirus incidence in 3,137 men.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод в очереди
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Dube Mandishora Racheal S, Dickey Brittney L, Fan Wenyi, Sirak Bradley, Isaacs-Soriano Kimberly, Rathwell Julie, Abrahamsen Martha, Reich Richard R, Schell Michael J, Lazcano-Ponce Eduardo, Villa Luisa L, Giuliano Anna R
Аннотация
Oral human papillomavirus (HPV) is associated with oropharyngeal cancer (OPC). Although OPC incidence is increasing globally, knowledge of oral HPV infection rates is limited. Here we carried out an observational epidemiological analysis of oral HPV incidence in 3,137 men enrolled from the United States, Mexico and Brazil between 2005 and 2009. Individuals were followed for new HPV infection for a median of 57 months. Cumulative incidence and factors associated with acquisition were also assessed. The incidence rate of oral oncogenic HPV was 2.4 per 1,000 person-months, did not vary with age and was constant throughout the study period. Risk of oral HPV acquisition was significantly associated with alcohol consumption, having male sexual partners, more lifetime female sexual partners, more oral sex given and higher educational attainment. These data indicate that men are at risk of acquiring oral HPV throughout their lifetime, suggesting that catch-up vaccination may reduce new infection incidence.