Clinical characteristics and risk factors of patients with cystic fibrosis-related diabetes and pre-diabetes: cohort of cystic fibrosis registry of Türkiye.
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Özaslan Mehmet Mustafa, Kartal Öztürk Gökçen, Gülen Figen, Demirdöğen Ezgi, Çobanoğlu Nazan, Tekin Merve Nur, Bingöl Ayşen, Başaran Abdurrahman Erdem, Şen Velat, Ünal Edip, Doğru Sibel, Özsezen Beste, Köse Mehmet, Ersoy Ali, Kılıç Mehmet, Yüksel Hasan, Kılıç Başkan Azer, Kılınç Sakallı Ayşe Ayzıt, Çakır Erkan, Hızal Mina, Anıl Hülya, Şişmanlar Eyüboğlu Tuğba, Kekeç Handan, Tana Aslan Ayşe, Yıldız Kayaoğlu Meltem, Altay Tanyer Emine, Emiralioğlu Nagehan, Yalçın Ebru, Pekcan Sevgi, Savaş Suat, Tokdemir Bahar Ece, Altıntaş Derya Ufuk, Serbes Mahir, Özdemir Ali, Karcıoğlu Oğuz, Elçi Burak Kağan, Canıtez Yakup, Özçelik Uğur, Doğru Ersöz Deniz
Аннотация
METHODS: All patients with CF who underwent diabetes screening in 2022 or earlier were included in the study. The clinical and demographic characteristics of patients with CFRD, pre-diabetes (impaired glucose tolerance, impaired fasting glucose, indeterminate glucose tolerance), and those with normal screening results (NSR) were compared.
RESULTS: Of the 1,702 patients registered in the data system in 2022, 916 patients from 21 centers who underwent diabetes screening were included in the study. CFRD was diagnosed in 102 patients (11.2 %), there were 56 patients (6.1 %) with pre-diabetes, and NSR were found in 757 patients (82.7 %). The youngest patient diagnosed with diabetes was 6 years old. In patients with CFRD, the median age of patients was found to be higher (p<0.001), body mass index (BMI) was found to be lower (p 0.017); chronic Pseudomonas aeruginosa (P. aeruginosa) colonization (p<0.001), severe mutations (60.8 %, p<0.001), and pancreatic insufficiency (56.1 %, p<0.001) were more frequent; median FEV1% and FVC% values were significantly lower (p<0.001 and p<0.002, respectively) compared to non-diabetic patients.
CONCLUSIONS: CFRD is associated with impaired pulmonary function, poor nutritional status, and increased chronic bacterial colonization of the airways. Advanced age, decreased respiratory function, severe genotype, and pancreatic insufficiency are risk factors for CFRD.