Gaceta medica de Mexico · 2008
[Posttransplant relapse in non viral hepatopathies].
Аннотация на английскомСтатьяНазвание и аннотация: Перевод в очереди
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Muñoz-Espinosa Linda Elsa, Martínez-García Alnitak, del Castillo Oralia, Cordero-Pérez Paula, Caballero-Mendoza Eloy, Pérez-Rodríguez Edelmiro, Hernández Guedea Marco Antonio, Elizondo-Riojas Guillermo, Escobedo-Villarreal Miguel
Аннотация
OBJECTIVE: We describe the recurrence of non-viral liver disease after orthotopic liver transplantation (OLT).
METHODS AND RESULTS: We studied 39 patients who received an OLT for non-viral chronic liver disease. Six (15.3%) of these patients presented disease recurrence after OLT, one following alcohol abuse, 3 presented autoimmune liver disease [2 received an OLT for primary biliary cirrhosis and recurred as autoimmune hepatitis (AIH) one patient had cryptogenic cirrhosis before OLT and recurred as AIH]. One patient showed recurrence of a non-alcoholic steatohepatitis (NASH). One patient received an OLT for cirrhosis secondary to the use of metothrexate and post OLT developed secondary biliary cirrhosis due to a choledocal stenosis in the anastomotic site.
CONCLUSIONS: All patients described here displayed long term recurrence (after 11 months post OLT). The recurrence of alcoholism was 8.3% among patients transplanted for this condition. AIH was observed in 30% of cases and NASH in 20%. All three patients with autoimmune liver disease recurred with a different autoimmune disease post OLT.
METHODS AND RESULTS: We studied 39 patients who received an OLT for non-viral chronic liver disease. Six (15.3%) of these patients presented disease recurrence after OLT, one following alcohol abuse, 3 presented autoimmune liver disease [2 received an OLT for primary biliary cirrhosis and recurred as autoimmune hepatitis (AIH) one patient had cryptogenic cirrhosis before OLT and recurred as AIH]. One patient showed recurrence of a non-alcoholic steatohepatitis (NASH). One patient received an OLT for cirrhosis secondary to the use of metothrexate and post OLT developed secondary biliary cirrhosis due to a choledocal stenosis in the anastomotic site.
CONCLUSIONS: All patients described here displayed long term recurrence (after 11 months post OLT). The recurrence of alcoholism was 8.3% among patients transplanted for this condition. AIH was observed in 30% of cases and NASH in 20%. All three patients with autoimmune liver disease recurred with a different autoimmune disease post OLT.