Acta physiologica et pharmacologica Bulgarica · 2001
A-waves in patients with novel hereditary motor and sensory neuropathy Lom.
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Alexandrov A S, Christova L G, Ishpekova B A
Аннотация
OBJECTIVES: To determine A-waves of a family with autosomal recessive form of demyelinatig hereditary motor and sensory neuropathy Lom (HMSNL).
METHODS: A-waves were investigated during conventional F-wave study of family members with HMSNL which had genetic testing.
RESULTS: During routine F-wave studies A-waves were observed in all tested nerves. They appeared between M-responses and F-wave. The A-waves were with low amplitude, shorter duration and constant shape and latency than F-waves. They appeared independently of F-waves. A-waves were more often recorded as multiple waves in lower and upper extremities. More than three A-waves per nerve were found mostly in ulnar and facial nerves. In 16 cases A-waves were found in the absence of F-waves.
CONCLUSION: It is assumed that the A-waves could be seen as additional signs of pathology because they were not observed in unaffected members of the family and in healthy subjects.
METHODS: A-waves were investigated during conventional F-wave study of family members with HMSNL which had genetic testing.
RESULTS: During routine F-wave studies A-waves were observed in all tested nerves. They appeared between M-responses and F-wave. The A-waves were with low amplitude, shorter duration and constant shape and latency than F-waves. They appeared independently of F-waves. A-waves were more often recorded as multiple waves in lower and upper extremities. More than three A-waves per nerve were found mostly in ulnar and facial nerves. In 16 cases A-waves were found in the absence of F-waves.
CONCLUSION: It is assumed that the A-waves could be seen as additional signs of pathology because they were not observed in unaffected members of the family and in healthy subjects.