Connective tissue research · 2025
Interleukin-4-loaded calcium alginate composite granules for hemostasis and alveolar bone regeneration after tooth extraction.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Ошибки и ограничения
История · было → стало
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Luo Zhengwen, Li Kuang-Wen, Yu Chengcheng, Yang Tianjiao, Lin Huajun, Chen Luyuan, Chen Zhihui, Zhao Tingting, Hong Yonglong, Sui Wen
Аннотация
PURPOSE/AIM: Tooth extraction often leads to postoperative bleeding and alveolar bone loss, complicating the healing process. This study aimed to develop interleukin-4 (IL-4)-loaded calcium alginate composite granules (CA@IL-4) as a dual-functional biomaterial to synergistically address these challenges by promoting both hemostasis and bone regeneration.
METHODS: The CA@IL-4 composite granules were successfully synthesized and characterized. Their biocompatibility and structural stability were evaluated in vitro. The efficacy of the granules was further investigated in a rat tooth extraction model, where hemostatic performance (bleeding time and blood loss) and regenerative capacity were assessed.
RESULTS: The synthesized CA@IL-4 material exhibited excellent biocompatibility and stability. In the animal model, CA@IL-4 granules achieved rapid hemostasis, significantly reducing both bleeding time and blood loss compared to the control. Micro-computed tomography and histological analyses after 28 days of healing confirmed that the CA@IL-4 group markedly enhanced alveolar bone regeneration, demonstrating superior bone mineral density (BMD), bone volume fraction (BV/TV), and trabecular architecture compared to the CA-only and untreated groups.
CONCLUSIONS: The CA@IL-4 composite granule is a promising dual-functional biomaterial that effectively promotes hemostasis and enhances bone regeneration, offering a potent strategy for optimal post-extraction socket management.
METHODS: The CA@IL-4 composite granules were successfully synthesized and characterized. Their biocompatibility and structural stability were evaluated in vitro. The efficacy of the granules was further investigated in a rat tooth extraction model, where hemostatic performance (bleeding time and blood loss) and regenerative capacity were assessed.
RESULTS: The synthesized CA@IL-4 material exhibited excellent biocompatibility and stability. In the animal model, CA@IL-4 granules achieved rapid hemostasis, significantly reducing both bleeding time and blood loss compared to the control. Micro-computed tomography and histological analyses after 28 days of healing confirmed that the CA@IL-4 group markedly enhanced alveolar bone regeneration, demonstrating superior bone mineral density (BMD), bone volume fraction (BV/TV), and trabecular architecture compared to the CA-only and untreated groups.
CONCLUSIONS: The CA@IL-4 composite granule is a promising dual-functional biomaterial that effectively promotes hemostasis and enhances bone regeneration, offering a potent strategy for optimal post-extraction socket management.