[Primary central nervous system lymphoma: A thirteen-year experience of a pediatric hematology and oncology department in Casablanca].

We conducted a retrospective study of 39 cases of primary cerebral lymphoma (PCL) collected in our hematology department over a 13-year period from January 2011 to December 2023. Our aim was to provide an overview of PCL in our patients. The mean age was 48 years with a male predominance. Clinical symptoms were polymorphic and nonspecific, but dominated by focal neurological deficits. Lesions were usually solitary and located at the supratentorial level. Pathological diagnosis was made after stereotactic biopsy in 32 patients and after surgical excision in 7 patients. The most common histological type was diffuse large B-cell lymphoma. All patients were included in the LCP protocol: polychemotherapy with high-dose methotrexate followed by consolidation with encephalic radiotherapy. Ten patients relapsed, including 8 in the brain and 2 in the testes. Overall, evaluation of the LCP protocol showed CR in 14 patients, death in 16 and 9 patients lost to follow-up. Overall and progression-free survival at 5 years was 40.36%, and 36.7% respectively.