Childhood central nervous system tumours: Incidence and time trends in 13 Southern and Eastern European cancer registries.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Papathoma Paraskevi, Thomopoulos Thomas P, Karalexi Maria A, Ryzhov Anton, Zborovskaya Anna, Dimitrova Nadya, Zivkovic Snezana, Eser Sultan, Antunes Luís, Sekerija Mario, Zagar Tina, Bastos Joana, Demetriou Anna, Cozma Raluca, Coza Daniela, Bouka Evdoxia, Dessypris Nick, Kantzanou Maria, Kanavidis Prodromos, Dana Helen, Hatzipantelis Emmanuel, Moschovi Maria, Polychronopoulou Sophia, Pourtsidis Apostolos, Stiakaki Eftichia, Papakonstantinou Evgenia, Oikonomou Konstantinos, Sgouros Spyros, Vakis Antonios, Zountsas Basilios, Bourgioti Charis, Kelekis Nikolaos, Prassopoulos Panos, Choreftaki Theodosia, Papadopoulos Savvas, Stefanaki Kalliopi, Strantzia Katerina, Cardis Elisabeth, Steliarova-Foucher Eva, Petridou Eleni Th
Аннотация
METHODS: All CNS tumours, as defined by the International Classification of Childhood Cancer (ICCC-3) and registered in any period between 1983 and 2014 were collected from the collaborating cancer registries. Data were evaluated using standard International Agency for Research on Cancer (IARC) criteria. Crude and age-adjusted incidence rates (AIR) by age/gender/diagnostic subgroup were calculated, whereas time trends were assessed through Poisson and Joinpoint regression models.
RESULTS: 6062 CNS tumours were retrieved with non-malignant CNS tumours recorded in eight registries; therefore, the analyses were performed on 5191 malignant tumours. Proportion of death certificate only cases was low and morphologic verification overall high; yet five registries presented >10% unspecified neoplasms. The male/female ratio was 1.3 and incidence decreased gradually with age, apart from Turkey and Ukraine. Overall AIR for malignant tumours was 23/10(6) children, with the highest rates noted in Croatia and Serbia. A statistically significant AIR increase was noted in Bulgaria, whereas significant decreases were noted in Belarus, Croatia, Cyprus and Serbia. Although astrocytomas were overall the most common subgroup (30%) followed by embryonal tumours (26%), the latter was the predominant subgroup in six registries.
CONCLUSION: Childhood cancer registration is expanding in Southern-Eastern Europe. The heterogeneity in registration practices and incidence patterns of CNS tumours necessitates further investigation aiming to provide clues in aetiology and direct investments into surveillance and early tumour detection.