Journal of vascular and interventional radiology : JVIR · 2024
Endovascular Therapy versus Anticoagulation Alone for Subacute Iliofemoral Deep Vein Thrombosis.
СтатьяСравнительное исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Huang Qun, Zhang Xing, Zhang Linjie, Qin Jinbao, Yang Xinrui, Ye Kaichuang, Lu Xinwu, Wang Ruihua, Peng Zhiyou
Аннотация
PURPOSE: To evaluate whether endovascular therapy (ET) improved early symptom relief and decreased the incidence of moderate-to-severe postthrombotic syndrome (PTS) compared with anticoagulation alone in patients with subacute (15-28 days) iliofemoral deep vein thrombosis (DVT).
MATERIALS AND METHODS: Consecutive patients with subacute iliofemoral DVT from January 2020 to June 2022 were identified. A total of 86 patients were assigned to receive treatment with ET alongside anticoagulation (endovascular group, n = 49) or anticoagulation alone (anticoagulation group, n = 37). Effectiveness outcomes including thrombus clearance rate, symptoms relief in 3 days (pain and swelling score), moderate-to-severe PTS rate, Villalta score, and Venous Clinical Severity Score (VCSS) at 12 months as well as safety outcomes including major bleeding, minor bleeding, and death within 12 months were compared between the 2 groups.
RESULTS: The endovascular group demonstrated greater symptoms relief in 3 days (1.1 ± 1.0 vs 3.6 ± 1.1; P < .001). The mean follow-up duration was 15.9 months for the endovascular group and 14.7 months for the anticoagulation group. Seventy-nine patients (91.8%) completed the 12-month follow-up. Villalta score (3.9 ± 2.6 vs 5.7 ± 4.3; P = .027), moderate-to-severe PTS (6.5% vs 27.3%; P = .011), and VCSS (2.3 ± 1.6 vs 3.6 ± 2.6; P = .004) at 12 months were significantly lower in the endovascular group. No significant differences were observed regarding minor bleeding events, recurrence of symptomatic DVT, and deaths between the 2 groups.
CONCLUSIONS: In patients with subacute iliofemoral DVT, the addition of ET to anticoagulation provided greater early symptoms relief and reduced the occurrence of moderate-to-severe PTS, with similar safety outcomes.
MATERIALS AND METHODS: Consecutive patients with subacute iliofemoral DVT from January 2020 to June 2022 were identified. A total of 86 patients were assigned to receive treatment with ET alongside anticoagulation (endovascular group, n = 49) or anticoagulation alone (anticoagulation group, n = 37). Effectiveness outcomes including thrombus clearance rate, symptoms relief in 3 days (pain and swelling score), moderate-to-severe PTS rate, Villalta score, and Venous Clinical Severity Score (VCSS) at 12 months as well as safety outcomes including major bleeding, minor bleeding, and death within 12 months were compared between the 2 groups.
RESULTS: The endovascular group demonstrated greater symptoms relief in 3 days (1.1 ± 1.0 vs 3.6 ± 1.1; P < .001). The mean follow-up duration was 15.9 months for the endovascular group and 14.7 months for the anticoagulation group. Seventy-nine patients (91.8%) completed the 12-month follow-up. Villalta score (3.9 ± 2.6 vs 5.7 ± 4.3; P = .027), moderate-to-severe PTS (6.5% vs 27.3%; P = .011), and VCSS (2.3 ± 1.6 vs 3.6 ± 2.6; P = .004) at 12 months were significantly lower in the endovascular group. No significant differences were observed regarding minor bleeding events, recurrence of symptomatic DVT, and deaths between the 2 groups.
CONCLUSIONS: In patients with subacute iliofemoral DVT, the addition of ET to anticoagulation provided greater early symptoms relief and reduced the occurrence of moderate-to-severe PTS, with similar safety outcomes.