Effects of Hytallzen™ on Growth-Related Parameters in Growing Male Rats.

Background/Objectives: Hytallzen™ is a natural combined extract of Artemisia princeps and Thymus vulgaris. The present study evaluated its growth-promoting effects during the rapid growth period in male Sprague-Dawley rats. Methods: Hytallzen™ (150 mg/kg/day) was orally administered for 9 weeks beginning at postnatal week 3. Growth-related parameters, including body weight, body length, food intake, serum insulin-like growth factor-1 (IGF-1), and tibia length and weight, were assessed. Results: Hytallzen™ significantly increased body weight, body length, food intake, tibia length, and tibia weight compared with controls. In addition, serum IGF-1 concentration was significantly elevated at week 6 and showed positive correlations with final body weight, body length, tibia length, and tibia weight. Conclusions: These findings suggest that Hytallzen™ is associated with favorable changes in growth-related parameters and serum IGF-1 levels in healthy growing rats, supporting its potential as a growth-supportive material under normal physiological growth conditions.