Boletin medico del Hospital Infantil de Mexico · 2024
Graft-versus-host disease variety toxic epidermal necrolysis. Case report.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Ошибки и ограничения
История · было → стало
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Zúñiga-Lara Elsa M, Zambrano-Virgen César M, Gaytán-Morales José F, Mendoza-Camargo Fredenet O, Gómez-Domínguez Yazmin A
Аннотация
BACKGROUND: We present the case of a patient who underwent hematopoietic progenitor cell transplantation from a fully compatible unrelated donor and subsequently developed Grade IV skin graft-versus-host disease (GVHD) resembling toxic epidermal necrolysis (TEN).
CLINICAL CASE: An 11-year-old female, post-transplantation of hematopoietic progenitor cells from a 100% compatible unrelated donor, developed rash-like skin lesions on the trunk and extremities on day +35. A skin biopsy revealed dermal atrophy, vacuolization of the basal layer, and confluent apoptotic keratinocytes with mononuclear inflammatory cells in the dermoepidermis, confirming the diagnosis of TENlike acute cutaneous GVHD.
CONCLUSION: The patient experienced an 80% remission of symptoms following dynamic management of immunosuppressants.
CLINICAL CASE: An 11-year-old female, post-transplantation of hematopoietic progenitor cells from a 100% compatible unrelated donor, developed rash-like skin lesions on the trunk and extremities on day +35. A skin biopsy revealed dermal atrophy, vacuolization of the basal layer, and confluent apoptotic keratinocytes with mononuclear inflammatory cells in the dermoepidermis, confirming the diagnosis of TENlike acute cutaneous GVHD.
CONCLUSION: The patient experienced an 80% remission of symptoms following dynamic management of immunosuppressants.