The journal of prevention of Alzheimer's disease · 2025
Association of vitamin B12 deficiency in a dementia cohort with hippocampal atrophy on MRI.
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Ueno Asako, Hamano Tadanori, Nagata Miwako, Yamaguchi Tomohisa, Endo Yoshinori, Enomoto Soichi, Kimura Hirohiko, Ikawa Masamichi, Yamamura Osamu, Yamanaka Daiki, Kimura Yohei, Nakamoto Yasunari, Nishiyama Yasuhiro
Аннотация
BACKGROUND: Vitamin deficiencies have been reported to cause brain atrophy. Hippocampal atrophy has been well reported in patients with dementia including Alzheimer's disease.
OBJECTIVES: To investigate the association between hippocampal atrophy and vitamin deficiency DESIGN: Cross sectional study SETTING: Three sites in one country PARTICIPANTS: Overall, 567 patients who visited an outpatient dementia clinic and underwent MRI-VSRAD (Voxel-Based Specific RegionalAnalysis System for Alzheimer's Disease) were included in this study.
INTERVENTION: Patients with a hippocampal atrophy Z-score of < 2 were classified as normal (n = 323), and those with a Z-score of ≥ 2 were diagnosed with hippocampal atrophy (n = 244).
MEASUREMENTS: Vitamin B12, folic acid, vitamin B1, homocysteine, HbA1c, and creatinine levels were measured and their association with hippocampal atrophy was assessed. Age, MMSE (Mini Mental State Examination), and hippocampal atrophy were also evaluated.
RESULTS: In the hippocampal atrophy group, the frequency of vitamin B12 deficiency was higher (p < 0.022), MMSE score was lower (p < 0.0001), and age was higher (p < 0.0001) than that in the normal group (Mann-Whitney U test). Patients with vitamin B12 deficiency (odds ratio, 3.46) and low MMSE score (odds ratio, 2.24) had an increased risk of hippocampal atrophy.
CONCLUSION: Vitamin B12 deficiency was associated with hippocampal atrophy detected by VSRAD analysis. Therefore, early vitamin B12 supplementation should be considered in patients with deficiencies to reduce dementia risk.
OBJECTIVES: To investigate the association between hippocampal atrophy and vitamin deficiency DESIGN: Cross sectional study SETTING: Three sites in one country PARTICIPANTS: Overall, 567 patients who visited an outpatient dementia clinic and underwent MRI-VSRAD (Voxel-Based Specific RegionalAnalysis System for Alzheimer's Disease) were included in this study.
INTERVENTION: Patients with a hippocampal atrophy Z-score of < 2 were classified as normal (n = 323), and those with a Z-score of ≥ 2 were diagnosed with hippocampal atrophy (n = 244).
MEASUREMENTS: Vitamin B12, folic acid, vitamin B1, homocysteine, HbA1c, and creatinine levels were measured and their association with hippocampal atrophy was assessed. Age, MMSE (Mini Mental State Examination), and hippocampal atrophy were also evaluated.
RESULTS: In the hippocampal atrophy group, the frequency of vitamin B12 deficiency was higher (p < 0.022), MMSE score was lower (p < 0.0001), and age was higher (p < 0.0001) than that in the normal group (Mann-Whitney U test). Patients with vitamin B12 deficiency (odds ratio, 3.46) and low MMSE score (odds ratio, 2.24) had an increased risk of hippocampal atrophy.
CONCLUSION: Vitamin B12 deficiency was associated with hippocampal atrophy detected by VSRAD analysis. Therefore, early vitamin B12 supplementation should be considered in patients with deficiencies to reduce dementia risk.