Drug and alcohol dependence · 2026
Non-fatal GHB overdose among sexual and gender minorities: A syndemic perspective.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Chavez Jennifer V, Guo Yan, Larson Michaela E, Westmoreland Drew A, D'Angelo Alexa B, Tsai Alexander C, Bartholomew Tyler S, Nash Denis, Grov Christian, Carrico Adam W
Аннотация
AIMS: This study examined prevalence and correlates of non-fatal gamma-hydroxybutyrate (GHB) overdose in sexual and gender minority (SGM) people.
METHODS: Cross sectional analyses leveraged baseline data from a subset of 1815 participants from US cohort of SGM people that reported recent GHB use. The outcome was any self-reported nonfatal GHB overdose in the past year. The exposure was a syndemic burden score (0-4), based on the presence of depressive symptoms and hypersexual disorder, childhood sexual assault, and intimate partner violence. Multivariable logistic regression was used to examine correlates of overdose. Sensitivity analyses assessed interactions between syndemic conditions using the relative excess risk due to interaction to assess associations beyond an additive model.
RESULTS: Among the 1815 participants who used GHB, 244 (13%) reported a past year overdose. Compared to those with 0-1 syndemic conditions, those with two (aOR = 3.02; 95% CI: 1.89, 5.05; p < 0.001), three (aOR = 3.19; 95% CI: 1.96, 5.41; p < 0.001) and four conditions (aOR = 5.63; 95% CI: 3.02,10.70; p < 0.001) had higher odds of reporting a GHB overdose. Hazardous alcohol use and residing in an Ending the HIV Epidemic (EHE) jurisdiction had higher odds of syndemic factors. No significant interaction effects between syndemic factors were found in sensitivity analyses.
CONCLUSIONS: More than one-in-ten SGM people who use GHB report at least one overdose in the past year. Interventions are needed especially for those reporting hazardous alcohol use and residing in EHE regions.
METHODS: Cross sectional analyses leveraged baseline data from a subset of 1815 participants from US cohort of SGM people that reported recent GHB use. The outcome was any self-reported nonfatal GHB overdose in the past year. The exposure was a syndemic burden score (0-4), based on the presence of depressive symptoms and hypersexual disorder, childhood sexual assault, and intimate partner violence. Multivariable logistic regression was used to examine correlates of overdose. Sensitivity analyses assessed interactions between syndemic conditions using the relative excess risk due to interaction to assess associations beyond an additive model.
RESULTS: Among the 1815 participants who used GHB, 244 (13%) reported a past year overdose. Compared to those with 0-1 syndemic conditions, those with two (aOR = 3.02; 95% CI: 1.89, 5.05; p < 0.001), three (aOR = 3.19; 95% CI: 1.96, 5.41; p < 0.001) and four conditions (aOR = 5.63; 95% CI: 3.02,10.70; p < 0.001) had higher odds of reporting a GHB overdose. Hazardous alcohol use and residing in an Ending the HIV Epidemic (EHE) jurisdiction had higher odds of syndemic factors. No significant interaction effects between syndemic factors were found in sensitivity analyses.
CONCLUSIONS: More than one-in-ten SGM people who use GHB report at least one overdose in the past year. Interventions are needed especially for those reporting hazardous alcohol use and residing in EHE regions.