Neuroreport · 2025
Multimodal MRI characterization of brain injury in heatstroke: integrating gray matter morphometry and advanced diffusion tractometry.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Li Xu, Qu Zhengwei, Miao Shengyan, Zhang Wenzheng, Li Wen, Zhang Xueyan, Li Jun
Аннотация
OBJECTIVE: To investigate gray-white matter injury in heatstroke using multimodal MRI, and precisely localize damaged white matter segments via automated fiber quantification (AFQ) with clinical correlation.
RESULTS: Compared with the healthy control group, VBM revealed reduced volume in bilateral cerebellar anterior lobes and left fusiform gyrus. TBSS showed widespread white matter abnormalities. AFQ identified: (a) Decreased fractional anisotropy in left corticospinal tract and right inferior fronto-occipital fasciculus; (b) increased mean diffusivity in left thalamic radiation, bilateral corticospinal tracts, corpus callosum forceps minor, bilateral inferior fronto-occipital fasciculus, left inferior longitudinal fasciculus, right superior longitudinal fasciculus, and bilateral uncinate fasciculi (false discovery rate - P < 0.05). Specific nodes in the left thalamic radiation, right corticospinal tract, right inferior fronto-occipital fasciculus, left inferior longitudinal fasciculus, and left uncinate fasciculus were correlated with Glasgow Coma Scale and coagulopathy markers.
CONCLUSION: Heatstroke involves cerebellar/cortical atrophy and segment-specific white matter damage, where AFQ-precise localization links microstructural alterations to clinical severity and coagulopathy.
RESULTS: Compared with the healthy control group, VBM revealed reduced volume in bilateral cerebellar anterior lobes and left fusiform gyrus. TBSS showed widespread white matter abnormalities. AFQ identified: (a) Decreased fractional anisotropy in left corticospinal tract and right inferior fronto-occipital fasciculus; (b) increased mean diffusivity in left thalamic radiation, bilateral corticospinal tracts, corpus callosum forceps minor, bilateral inferior fronto-occipital fasciculus, left inferior longitudinal fasciculus, right superior longitudinal fasciculus, and bilateral uncinate fasciculi (false discovery rate - P < 0.05). Specific nodes in the left thalamic radiation, right corticospinal tract, right inferior fronto-occipital fasciculus, left inferior longitudinal fasciculus, and left uncinate fasciculus were correlated with Glasgow Coma Scale and coagulopathy markers.
CONCLUSION: Heatstroke involves cerebellar/cortical atrophy and segment-specific white matter damage, where AFQ-precise localization links microstructural alterations to clinical severity and coagulopathy.