Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026
Pediatric idiopathic intracranial hypertension: prognostic value of obesity and cerebrospinal fluid pressure.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Bedir Fırat, Nuhoğlu Çağatay
Аннотация
BACKGROUND: Pediatric idiopathic intracranial hypertension (IIH) is a rare but potentially vision-threatening disorder.
OBJECTIVE: This study aimed to evaluate the clinical characteristics, prognostic indicators, and outcomes in pediatric IIH, with a specific focus on the effects of obesity and cerebrospinal fluid (CSF) opening pressure.
METHODS: Twenty-six children under 18 years of age, diagnosed according to the revised Friedman criteria, were retrospectively analyzed. Clinical, ophthalmologic, and neuroimaging data were collected. Correlation and logistic regression analyses were performed to determine predictors of residual visual deficit.
RESULTS: The mean age was 11.2 ± 3.4 years, and 53.8% of the patients were female. Overweight and obesity were observed in 34.6% and 19.2% of cases, respectively. Headache (80.7%) and papilledema (76%) were the most common findings. The mean CSF opening pressure was 335 ± 85 mmH₂O. A significant correlation was found between CSF pressure and papilledema grade (r = 0.41, p = 0.04). In the exploratory multivariable logistic regression analysis, elevated CSF opening pressure was associated with residual visual deficit (OR 3.2, 95% CI 1.1-9.1, p = 0.04).
CONCLUSION: Elevated CSF opening pressure and obesity appear to be associated with visual outcomes in pediatric IIH. Early recognition and multidisciplinary management may help prevent irreversible visual loss and improve long-term prognosis.
OBJECTIVE: This study aimed to evaluate the clinical characteristics, prognostic indicators, and outcomes in pediatric IIH, with a specific focus on the effects of obesity and cerebrospinal fluid (CSF) opening pressure.
METHODS: Twenty-six children under 18 years of age, diagnosed according to the revised Friedman criteria, were retrospectively analyzed. Clinical, ophthalmologic, and neuroimaging data were collected. Correlation and logistic regression analyses were performed to determine predictors of residual visual deficit.
RESULTS: The mean age was 11.2 ± 3.4 years, and 53.8% of the patients were female. Overweight and obesity were observed in 34.6% and 19.2% of cases, respectively. Headache (80.7%) and papilledema (76%) were the most common findings. The mean CSF opening pressure was 335 ± 85 mmH₂O. A significant correlation was found between CSF pressure and papilledema grade (r = 0.41, p = 0.04). In the exploratory multivariable logistic regression analysis, elevated CSF opening pressure was associated with residual visual deficit (OR 3.2, 95% CI 1.1-9.1, p = 0.04).
CONCLUSION: Elevated CSF opening pressure and obesity appear to be associated with visual outcomes in pediatric IIH. Early recognition and multidisciplinary management may help prevent irreversible visual loss and improve long-term prognosis.