Nature communications · 2025
Regional heterogeneity of the blood-brain barrier.
СтатьяНазвание и аннотация: Перевод в очереди
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Blanchette Marie, Bajc Kaja, Gastfriend Benjamin D, Profaci Caterina P, Ruderisch Nadine, Dorrier Cayce E, Zhong Guo, Cuevas-Diaz Duran Raquel, Harvey Sean S, Garcia-Pak Iris H, Pintarić Lucija, Leclerc Manon, Reveret Louise, Émond Vincent, Wang Annette, Pant Deepti, Tsai Linus T, Calon Frédéric, Isoherranen Nina, Palecek Sean P, Shusta Eric V, Wu Jiaqian, Daneman Richard
Аннотация
The blood-brain barrier (BBB), formed by specialized endothelial cells (ECs), regulates the extracellular composition of the central nervous system (CNS). Little is known about whether there are regional specializations of the BBB that may control the function of specific neural circuits. We use single cell RNA-seq to characterize ECs from nine CNS regions in male mice: cortex, hippocampus, cerebellum, spinal cord, striatum, thalamus, hypothalamus, midbrain, and medulla/pons. Although there is a core BBB transcriptional profile, there are significant regional specializations. Stra6, a retinoid transporter, is highly enriched in the BBB of the nucleus accumbens shell (ShNAc) and ventral cochlear nucleus, and is controlled by dietary vitamin A, through endothelial RARƔ. EC Stra6 regulates the deposition of retinoids specifically in the ShNAc and cochlear nucleus, and is required for the function of the ShNAc, in a retinoid-dependent manner. Thus regional specializations of the BBB can regulate the function of local brain regions.