Journal of the European Academy of Dermatology and Venereology : JEADV · 2025
Clinical heterogeneity in vitiligo: Identification of clinical markers based patient clusters.
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Galissi Laura, Benoît Tristan, Merhi Ribal, Drullion Claire, Andreu Nicolas, Ezzedine Khaled, Darde Thomas, Boniface Katia, Seneschal Julien
Аннотация
BACKGROUND: Vitiligo (non-segmental) is a chronic autoimmune skin disease leading to white patches. Although vitiligo has been delineated previously, the endophenotypes of the disease are still to be defined.
OBJECTIVES: The aim of this study was to investigate, without prior hypotheses, whether different clinical phenotypes of vitiligo could be identified and differ based on their demographic and clinical characteristics.
METHODS: This retrospective, non-interventional, single-centre study included patients with vitiligo. Demographic and clinical characteristics of vitiligo were recorded. Hierarchical cluster analysis was then performed.
RESULTS: A total of 399 patients were included. The cluster analysis classified the patients into five clusters as follows: (1) 'highly active patients' with elevated frequency of disease activity signs, receiving combinatorial topical and systemic therapy; (2) mild vitiligo patients with younger patients, low surface area involved and absence of signs of disease activity; (3) extensive vitiligo patients, with older patients and the largest surface area involved; (4) and (5) mild or moderate to severe disease, with localization of the lesions on site of chronic skin friction (type 2A koebner phenomenon).
CONCLUSIONS: Patients with vitiligo can be classified into five phenotypes, with two defining the highly active and extensive patients.
OBJECTIVES: The aim of this study was to investigate, without prior hypotheses, whether different clinical phenotypes of vitiligo could be identified and differ based on their demographic and clinical characteristics.
METHODS: This retrospective, non-interventional, single-centre study included patients with vitiligo. Demographic and clinical characteristics of vitiligo were recorded. Hierarchical cluster analysis was then performed.
RESULTS: A total of 399 patients were included. The cluster analysis classified the patients into five clusters as follows: (1) 'highly active patients' with elevated frequency of disease activity signs, receiving combinatorial topical and systemic therapy; (2) mild vitiligo patients with younger patients, low surface area involved and absence of signs of disease activity; (3) extensive vitiligo patients, with older patients and the largest surface area involved; (4) and (5) mild or moderate to severe disease, with localization of the lesions on site of chronic skin friction (type 2A koebner phenomenon).
CONCLUSIONS: Patients with vitiligo can be classified into five phenotypes, with two defining the highly active and extensive patients.