The American journal of gastroenterology · 2025
Elevation of tTG-IgA Antibodies in a Prospective Cohort of Children at Risk of Celiac Disease: Insights From the CDGEMM Cohort.
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Pucinischi Valentina, Kenyon Victoria, Montuori Monica, Piemontese Pasqua, Francavilla Ruggiero, Norsa Lorenzo, Di Nardo Giovanni, Baldassarre Maria Elisabetta, Trovato Maria Chiara, Perrone Michela, Passaro Tiziana, Sansotta Naire, Crocco Marco, Morelli Annalisa, Malerba Federica, Cristofori Fernanda, Elli Luca, Fasano Alessio, Valitutti Francesco, Leonard Maureen M, CDGEMM Team
Аннотация
Celiac disease (CeD) is a common immune-mediated condition that occurs in genetically predisposed individuals. In this study, we examined the trajectory of tissue transglutaminase IgA (tTG-IgA) antibodies in a prospective longitudinal cohort of over 500 children at risk of developing CeD due to having a first-degree relative with CeD. We identified 34 subjects from our cohort and examined tTG-IgA titers at seroconversion and 6 months before tTG-IgA seroconversion. We found that all subjects had normal tTG-IgA 6 months before seroconversion. Thus, we conclude that tTG-IgA elevation in subjects with CeD is a sudden event and its trajectory cannot be used as a marker to predict seroconversion in this population.