The Pathophysiology of Tics: An Anatomic Review.

The underlying pathophysiology of tics in Tourette syndrome is a topic of major scientific interest. To date, there is an absence of consensus among researchers regarding the precise anatomic location responsible for tics. The goal of this article is to review the current understanding of these brain circuits and data supporting specific anatomic regions. In summary, current scientific evidence supports the likelihood of multiple areas of abnormality within cortico-basal ganglia-thalamocortical (CBGTC) circuitry or their connected brain regions. A reasonable anatomic hypothesis is that a disruption anywhere within specific circuitry can ultimately lead to the development of a tic disorder.