[Investigation of damage of the gastric mucosal barrier by Helicobacter pylori].

Damage of the gastric mucosal barrier by Helicobacter pylori (Hp) has been investigated with estimation of antral mucosal hexosamine and phospholipid, and the degree of pathologic changes to be also evoluted in 100 cases of chronic superficial gastritis. There are 42% of 50 cases of Hp positive patients with active gastric lesions, and significantly high than 50 cases of Hp negative patients (8%). The mean value of antral mucosal hexosamine is 30.33 mg/g in Hp positive group, while in Hp negative group, the mean value is 36.98 mg/g (P < 0.005). The mean value of antral mucosal phospholipid is 31.96 mg/g in Hp positive. While in Hp negative is 36.49 mg/g (P < 0.05). So, estimation of mucosal hexosamine and phospholipid can be represent the degree of damage of gastric mucosal barrier. Hp should be considered as causative agent to break down the gastric mucosal barrier.