[Cardiac Perspective on Amyloidosis: Appropriate Cardiac Diagnostic Approaches Following Histological Amyloid Detection in Tendinopathies].

Amyloidosis is a rare, typically systemic disease that may cause progressive heart failure when cardiac involvement occurs. The two most common subtypes leading to cardiomyopathy - AL and ATTR amyloidosis - differ substantially in terms of diagnosis, treatment, and prognosis. Retrospective studies have shown that musculoskeletal manifestations such as carpal tunnel syndrome, stenosing tenosynovitis, Dupuytren's contracture, or tendon ruptures often occur years before the diagnosis of cardiac amyloidosis and may serve as early clinical markers. A risk-adapted, targeted histopathological work-up, combined with structured interdisciplinary follow-up care, can significantly contribute to the early detection of previously unrecognized systemic amyloidosis. This review highlights the growing importance of musculoskeletal manifestations in the hand surgery setting as potential early indicators of systemic amyloidosis and proposes a structured clinical pathway for interdisciplinary collaboration with cardiology and haematology.