Journal of drugs in dermatology : JDD · 2025
Skin Improvements in Acne Vulgaris Patients Using Gel-Matrix Moisturizer as a Complement to Topical Treatments.
СтатьяНазвание и аннотация: Перевод в очереди
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Bernhardt Katrina T, Zaleski Erin, Li Wen-Hwa, Parsa Ramine, Miller Dara, Draelos Zoe, Bianchini Julie M
Аннотация
BACKGROUND: A novel gel-matrix moisturizer was designed to 1) deliver immediate, long-lasting hydration benefits in a lightweight, non-greasy, noncomedogenic formula that is suitable for use on dry, oily, acne-prone, and sensitive skin; 2) reduce acne-related and acne medication–induced skin irritation and dryness; and 3) improve quality of life (QoL), when used as an adjunctive moisturizer by patients with acne using topical treatments.
OBJECTIVE: To assess the biological effects of the gel-matrix moisturizer on key epidermal proteins of skin barrier function, and clinical improvements in skin attributes and tolerability in adults with acne undergoing topical treatment.
METHODS: Preclinical and clinical studies evaluated the tolerability of the gel-matrix moisturizer and its effects on filaggrin and aquaporin-3 protein levels (markers of barrier function), skin texture, appearance, and QoL in the study population.
RESULTS: In skin explant studies, the gel-matrix moisturizer demonstrated significant increases in levels of filaggrin (+36%) and aquaporin-3 (+102%) versus untreated controls (both P<0.05). Clinically, at week 4 compared with baseline, the gel-matrix moisturizer demonstrated significant improvements in visual skin smoothness, roughness, clarity, radiance, pore issues, and overall skin appearance (all P<0.01), as well as significant decreases in skin itching (P<0.01) and tightness (P<0.002). Patients with acne also using topical over the counter and prescription treatments reported significant improvements in QoL at week 4 (P<0.001).
CONCLUSION: The gel-matrix moisturizer improved barrier function and skin attributes without exacerbating acne symptoms, offering suitable topical moisturization when used as an adjunctive moisturizer with acne treatments.  .
OBJECTIVE: To assess the biological effects of the gel-matrix moisturizer on key epidermal proteins of skin barrier function, and clinical improvements in skin attributes and tolerability in adults with acne undergoing topical treatment.
METHODS: Preclinical and clinical studies evaluated the tolerability of the gel-matrix moisturizer and its effects on filaggrin and aquaporin-3 protein levels (markers of barrier function), skin texture, appearance, and QoL in the study population.
RESULTS: In skin explant studies, the gel-matrix moisturizer demonstrated significant increases in levels of filaggrin (+36%) and aquaporin-3 (+102%) versus untreated controls (both P<0.05). Clinically, at week 4 compared with baseline, the gel-matrix moisturizer demonstrated significant improvements in visual skin smoothness, roughness, clarity, radiance, pore issues, and overall skin appearance (all P<0.01), as well as significant decreases in skin itching (P<0.01) and tightness (P<0.002). Patients with acne also using topical over the counter and prescription treatments reported significant improvements in QoL at week 4 (P<0.001).
CONCLUSION: The gel-matrix moisturizer improved barrier function and skin attributes without exacerbating acne symptoms, offering suitable topical moisturization when used as an adjunctive moisturizer with acne treatments.  .