Acta diabetologica · 2026
Exploring the role of resistin as a biomarker of early renal changes in pediatric type 1 diabetes mellitus.
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Bojanin Dragana, Stefanović Aleksandra, Vuković Rade, Mitrović Katarina, Vekić Jelena
Аннотация
AIMS: Evidence suggests that resistin, through its pro-inflammatory and pro-oxidative actions, may contribute to the development of cardiovascular and kidney diseases. Although resistin has been investigated in insulin-resistant states, data on this cytokine in pediatric patients with type 1 diabetes mellitus (T1DM) remain scarce. This study aimed to examine the relationship between circulating resistin and oxidative stress biomarkers, as well as with urinary albumin excretion in children and adolescents with T1DM.
METHODS: Serum resistin levels, metabolic control, lipid and redox biomarkers, including prooxidant-antioxidant balance (PAB), advanced oxidation protein products (AOPP), total sulfhydryl (SH) groups, superoxide dismutase (SOD) activity and total antioxidant status (TAS) were determined in 159 pediatric T1DM patients.
RESULTS: The highest resistin tertile was characterized by the largest proportion of poorly controlled patients (P < 0.05). These patients also showed significantly elevated AOPP and SH-groups, while the patients in the lowest tertile exhibited significantly higher PAB. Resistin correlated positively with urinary albumin excretion, AOPP and hsCRP, and negatively with PAB (P < 0.05). Patients in the highest resistin tertile had a greater likelihood of early elevation of albumin excretion (OR = 2.27; 97% CI: 1.00-5.15; P = 0.05). This relationship remained significant after adjustment for demographic, lipid and redox parameters, but attenuated after adjustment for diabetes-related parameters.
CONCLUSIONS: Elevated serum resistin concentrations in pediatric patients with T1DM were associated with suboptimal metabolic control, enhanced oxidative stress and an early increase in urinary albumin excretion rate. Further studies are needed to clarify the mechanisms through which resistin contributes to early kidney dysfunction in T1DM.
METHODS: Serum resistin levels, metabolic control, lipid and redox biomarkers, including prooxidant-antioxidant balance (PAB), advanced oxidation protein products (AOPP), total sulfhydryl (SH) groups, superoxide dismutase (SOD) activity and total antioxidant status (TAS) were determined in 159 pediatric T1DM patients.
RESULTS: The highest resistin tertile was characterized by the largest proportion of poorly controlled patients (P < 0.05). These patients also showed significantly elevated AOPP and SH-groups, while the patients in the lowest tertile exhibited significantly higher PAB. Resistin correlated positively with urinary albumin excretion, AOPP and hsCRP, and negatively with PAB (P < 0.05). Patients in the highest resistin tertile had a greater likelihood of early elevation of albumin excretion (OR = 2.27; 97% CI: 1.00-5.15; P = 0.05). This relationship remained significant after adjustment for demographic, lipid and redox parameters, but attenuated after adjustment for diabetes-related parameters.
CONCLUSIONS: Elevated serum resistin concentrations in pediatric patients with T1DM were associated with suboptimal metabolic control, enhanced oxidative stress and an early increase in urinary albumin excretion rate. Further studies are needed to clarify the mechanisms through which resistin contributes to early kidney dysfunction in T1DM.