Journal of the American College of Surgeons · 2010
Hepatitis B genotype C correlated with poor surgical outcomes for hepatocellular carcinoma.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод в очереди
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Liang Tsung-Jung, Mok King-Tong, Liu Shiuh-Inn, Huang Shiu-Feng, Chou Nan-Hua, Tsai Cheng-Chung, Chen I-Shu, Yeh Ming-Hsin, Chen Yu-Chia, Wang Being-Whey
Аннотация
BACKGROUND: Genotype B and C are the predominant hepatitis B virus (HBV) strains in Taiwan. We aimed to investigate the role of genotype in HBV-related hepatocellular carcinoma (HCC) after resection.
STUDY DESIGN: From October 2005 to November 2008, 64 patients who underwent liver resection for HBV-related HCC were enrolled. HBV genotypes were determined by molecular method. Patient characteristics, biochemical, tumor, and viral factors were evaluated for their prognostic significance.
RESULTS: During a mean follow-up of 26.6 ± 13.2 months, patients infected with genotype C had higher HBV viral load (p = 0.007) and worse disease-free survival rate (p = 0.028) than patients with genotype B. By univariate analysis, genotype C, alanine transaminase >50 U/L, tumor size ≥5 cm, and microvascular invasion were associated with tumor recurrence. Further multivariate analysis demonstrated genotype C remained a significant risk factor (p = 0.034).
CONCLUSIONS: Genotype C is a strong risk factor for HCC recurrence after resection. More intensive monitoring for recurrence should be considered in patients with genotype C.
STUDY DESIGN: From October 2005 to November 2008, 64 patients who underwent liver resection for HBV-related HCC were enrolled. HBV genotypes were determined by molecular method. Patient characteristics, biochemical, tumor, and viral factors were evaluated for their prognostic significance.
RESULTS: During a mean follow-up of 26.6 ± 13.2 months, patients infected with genotype C had higher HBV viral load (p = 0.007) and worse disease-free survival rate (p = 0.028) than patients with genotype B. By univariate analysis, genotype C, alanine transaminase >50 U/L, tumor size ≥5 cm, and microvascular invasion were associated with tumor recurrence. Further multivariate analysis demonstrated genotype C remained a significant risk factor (p = 0.034).
CONCLUSIONS: Genotype C is a strong risk factor for HCC recurrence after resection. More intensive monitoring for recurrence should be considered in patients with genotype C.
Предметные рубрики MeSH
Carcinoma, HepatocellularCausalityCause of DeathComorbidityDNA, ViralDisease-Free SurvivalFemaleFollow-Up StudiesGenotypeHepacivirusHepatitis BHepatitis B virusHumansLiver NeoplasmsMaleMiddle AgedMultivariate AnalysisNeoplasm Recurrence, LocalPeliosis HepatisRisk FactorsSurvival RateTreatment OutcomeViral Load