Science (New York, N.Y.) · 2026
Genomic predisposition is associated with the direction of sex chromosome evolution.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Zhou Yang, Jin Jiazheng, Jiang Chuan, Dudchenko Olga, Pinto Brendan J, Colaric Zane, Khan Ruqayya, Omer Arina D, Li Xuemei, Song Zhenzhen, Han Li, Chen Wanyi, Jiang Lichun, Song Zhangyue, Weisz David, Xia Yun, Qi Yin, Cao Zhengqing, Peng Yudian, Zhu Zexian, Zhou Qi, Liu Yan, Gu Xiaosong, Nielsen Stuart V, Griffing Aaron H, Ezaz Tariq, Georges Arthur, Brennan Ian, Aiden Erez Lieberman, Gamble Tony, Shi Peng, Zhang Guojie
Аннотация
Sex chromosome evolution is among the most dynamic genomic innovations in vertebrates, yet why some lineages evolve XY while others evolve ZW remains unclear. Using chromosome-level genomes from 19 geckos, we found that gecko sex chromosomes originated independently from 16 ancestral chromosomes. Their origins are nonrandom in both time and direction. Five of 11 datable origins coincide near the Middle Miocene Climatic Transition (~10 million years ago). Ancestral gene content is associated with the direction of evolution, with testis-enriched regions tending to evolve into ZW and testis-depleted regions into XY, a pattern observed across multiple amniote sex chromosome origins. Geckos with genetic sex determination repeatedly evolve partial dosage balance through up-regulation in the heterogametic sex. Sex chromosome evolution thus follows constraints from ancestral genomic predisposition and environmental context.