BMC infectious diseases · 2025
Aspergillus pseudomembranous tracheitis leading to tracheal cartilage exfoliation: uncommon disease with rare presentation.
СтатьяКлинический случайНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Wang Jiayue, Huang Jie, Liu Jidong, Cheng Xiaowei
Аннотация
BACKGROUND: While pulmonary aspergillosis constitutes a common fungal infection with typical respiratory manifestations, its association with tracheal cartilage exfoliation is an exceedingly rare complication. This report describes a case in a 55-year-old female, detailing the clinical presentation, therapeutic management, and follow-up to elucidate this unusual disease process.
CASE PRESENTATION: A middle-aged diabetic woman presented with cough, wheezing, and sputum. Imaging and bronchoscopy identified a tracheal mass, with biopsy confirming fungal (likely Aspergillus) infection.During intravenous voriconazole treatment, she coughed out a piece of cartilage, confirming tracheal invasion. Follow-up showed tracheal stenosis, granulation tissue, and cartilage destruction.Over the time her symptoms resolved. Follow-up CT showed stable tracheal narrowing, with good recovery.
CONCLUSION: Despite improved diagnostics for pulmonary fungal infections, tracheal cartilage exfoliation due to Aspergillus remains a serious concern. The fungus secretes endotoxins and proteases that cause tissue necrosis and cartilage invasion, leading to exfoliation prone to misdiagnosis and life-threatening asphyxia. Therefore, thorough patient education about this risk is essential.
CLINICAL TRIAL NUMBER: Not applicable.
CASE PRESENTATION: A middle-aged diabetic woman presented with cough, wheezing, and sputum. Imaging and bronchoscopy identified a tracheal mass, with biopsy confirming fungal (likely Aspergillus) infection.During intravenous voriconazole treatment, she coughed out a piece of cartilage, confirming tracheal invasion. Follow-up showed tracheal stenosis, granulation tissue, and cartilage destruction.Over the time her symptoms resolved. Follow-up CT showed stable tracheal narrowing, with good recovery.
CONCLUSION: Despite improved diagnostics for pulmonary fungal infections, tracheal cartilage exfoliation due to Aspergillus remains a serious concern. The fungus secretes endotoxins and proteases that cause tissue necrosis and cartilage invasion, leading to exfoliation prone to misdiagnosis and life-threatening asphyxia. Therefore, thorough patient education about this risk is essential.
CLINICAL TRIAL NUMBER: Not applicable.