Medicine · 2026
Vanishing bile duct syndrome induced by Psoraleae Fructus: A case report and literature review.
СтатьяКлинический случайОбзорНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Liu Min, Lei Chuang, Tian Hong-Ling, Wang Qing-Hai, Dong Xi-Yang
Аннотация
RATIONALE: Certain drugs can trigger inflammatory responses and necrosis in the interlobular bile duct epithelial cells of the liver. Persistent damage may cause bile duct disappearance and biliary cirrhosis. When over 50% of bile ducts are lost, drug-induced vanishing bile duct syndrome (VBDS), a rare yet severe clinical condition, can be diagnosed.
PATIENT CONCERNS: A 67-year-old woman had a radius fracture and took Chinese herbal medicine containing Psoraleae Fructus (PF) for 1 week, then developed jaundice and pruritus.
DIAGNOSES: Laboratory tests confirmed cholestatic liver injury, imaging studies ruled out biliary obstruction, and liver biopsy showed progressive disappearance of interlobular bile ducts, consistent with a VBDS diagnosis.
INTERVENTIONS: The patient received plasma exchange and hepatoprotective therapy.
OUTCOMES: After treatment, her liver function gradually improved.
LESSONS: PF may induce VBDS via immune or toxic mechanisms.
CONCLUSION: Clinicians should maintain a high level of suspicion for PF-associated liver injury and enhance monitoring and risk assessment during its clinical use.
PATIENT CONCERNS: A 67-year-old woman had a radius fracture and took Chinese herbal medicine containing Psoraleae Fructus (PF) for 1 week, then developed jaundice and pruritus.
DIAGNOSES: Laboratory tests confirmed cholestatic liver injury, imaging studies ruled out biliary obstruction, and liver biopsy showed progressive disappearance of interlobular bile ducts, consistent with a VBDS diagnosis.
INTERVENTIONS: The patient received plasma exchange and hepatoprotective therapy.
OUTCOMES: After treatment, her liver function gradually improved.
LESSONS: PF may induce VBDS via immune or toxic mechanisms.
CONCLUSION: Clinicians should maintain a high level of suspicion for PF-associated liver injury and enhance monitoring and risk assessment during its clinical use.