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Evaluation of serum amyloid A as a biomarker for sepsis diagnosis compared with C-reactive protein, procalcitonin, and presepsin.
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Kim Myeong Hee, Kang So Young, Lee Woo-In, Lee Min Young
Аннотация
INTRODUCTION: Several biomarkers have been developed for rapid and accurate diagnosis of sepsis. This study aimed to evaluate the potential of serum amyloid A (SAA) as a biomarker for sepsis diagnosis compared with C-reactive protein (CRP), procalcitonin (PCT), and presepsin.
METHODS: Biomarker levels were measured in 193 patients. Blood and microbial cultures were obtained from 69 and 94 patients, respectively. Based on the culture results and clinical symptoms, patients were classified into groups with sepsis, local infection, inflammatory disease, or other conditions to evaluate the differences in the values of the 4 biomarkers.
RESULTS: Serum amyloid A, CRP, and PCT levels were high in both the sepsis and localized infection groups, whereas SAA also showed increased levels in the inflammatory disease group. The area under the curve for diagnostic ability of SAA, CRP, PCT, and presepsin were 82.6%, 82.0%, 90.3%, and 85.7%, respectively. In the statistical association analysis, SAA showed a positive correlation with the 3 other biomarkers, with the best correlation observed with CRP.
DISCUSSION: The application of SAA in the early diagnosis of sepsis holds substantial clinical promise, particularly when employed alongside established biomarkers such as PCT, CRP, and presepsin. This combinatory approach may enhance diagnostic accuracy.
METHODS: Biomarker levels were measured in 193 patients. Blood and microbial cultures were obtained from 69 and 94 patients, respectively. Based on the culture results and clinical symptoms, patients were classified into groups with sepsis, local infection, inflammatory disease, or other conditions to evaluate the differences in the values of the 4 biomarkers.
RESULTS: Serum amyloid A, CRP, and PCT levels were high in both the sepsis and localized infection groups, whereas SAA also showed increased levels in the inflammatory disease group. The area under the curve for diagnostic ability of SAA, CRP, PCT, and presepsin were 82.6%, 82.0%, 90.3%, and 85.7%, respectively. In the statistical association analysis, SAA showed a positive correlation with the 3 other biomarkers, with the best correlation observed with CRP.
DISCUSSION: The application of SAA in the early diagnosis of sepsis holds substantial clinical promise, particularly when employed alongside established biomarkers such as PCT, CRP, and presepsin. This combinatory approach may enhance diagnostic accuracy.