Causal Links Between Sleep Duration and Sarcopenia-Related Phenotypes: A Mendelian Randomization and Shared Genetic Mechanism Study.

BACKGROUND

Emerging observational research reported that sleep duration was linked to sarcopenia, yet these associations have not been ascertained causally.

METHOD: This study included data from the 2015-2018 National Health and Nutrition Examination Survey and applied multivariable logistic regression to evaluate the relationship between sleep duration and sarcopenia. A two-sample Mendelian randomization study was subsequently performed using genome-wide association study summary statistics to determine the causal relationships between sleep duration, appendicular lean mass, grip. Sensitivity analysis was performed to confirm the robustness of the results. Finally, summary data-based Mendelian randomization is used to explore their shared risk genes.

RESULTS

A total of 5243 participants were included in this study, and multivariable logistic regression analysis showed an inverse association between sleep duration and sarcopenia. Mendelian randomization analysis also supported long sleep duration are negatively correlated with appendicular lean mass, and sleep duration is negatively correlated with grip. In addition, reverse Mendelian randomization showed appendicular lean mass was negatively correlated with long sleep time. Summary data-based Mendelian randomization analysis further explored shared risk genes for each causal trait pair, and these genes are involved in biological processes.

CONCLUSIONS

By integrating genetic, pharmacological, and pathological data, we revealed a potential link between sleep duration and muscular dystrophy. These results provide new ideas for potential treatments and potential guidance for clinical practice.