Sleep matters: rethinking its role in growth hormone deficiency treatment.

PURPOSE: This letter has the purpose of alerting the medical community to the impact of sleep debt on growth hormone (GH) therapy, mostly applied to pediatric and puberty ages. METHODS: We discussed the role of sleep in GH release, especially N3 sleep. RESULTS: During sleep, hypothalamus is stimulated to secrete growth hormone–releasing hormone (GHRH) which activates synthesis and secretion of GH by anterior pituitary gland. Studies focusing on the interaction of sleep and GH release are scarce and have controversial results. Some studies have found a direct effect of N3 sleep in GH pulse, indicating the importance of adequate sleep during treatment in patients with GH deficiency. Modern lifestyles often lead to inadequate sleep, which can severely disrupt bodily functions, particularly in people with endocrine conditions, since sleep is essential for proper hormonal balance. CONCLUSION: For individuals demonstrating regression in GH therapy and reporting sleep-related concerns, the use of sleep hygiene practices or the exploration of possible sleep disorders can help advance therapeutic efficacy and overall patient well-being.