Toxicology in vitro : an international journal published in association with BIBRA · 2011
Analysis for the potential of polystyrene and TiO2 nanoparticles to induce skin irritation, phototoxicity, and sensitization.
Сравнительное исследованиеСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Park Yoon-Hee, Jeong Sang Hoon, Yi Sang Min, Choi Byeong Hyeok, Kim Yu-Ri, Kim In-Kyoung, Kim Meyoung-Kon, Son Sang Wook
Аннотация
The human skin equivalent model (HSEM) is well known as an attractive alternative model for evaluation of dermal toxicity. However, only limited data are available on the usefulness of a HSEM for nanotoxicity testing. This study was designed to investigate cutaneous toxicity of polystyrene and TiO2 nanoparticles using cultured keratinocytes, a HSEM, and an animal model. In addition, we also evaluated the skin sensitization potential of nanoparticles using a local lymph node assay with incorporation of BrdU. Findings from the present study indicate that polystyrene and TiO2 nanoparticles do not induce phototoxicity, acute cutaneous irritation, or skin sensitization. Results from evaluation of the HSEMs correspond well with those from animal models. Our findings suggest that the HSEM might be a useful alternative model for evaluation of dermal nanotoxicity.
Предметные рубрики MeSH
3T3 CellsAnimalsCell LineCell SurvivalColoring AgentsDermatitis, PhototoxicFemaleFibroblastsHumansHypersensitivityIn Vitro TechniquesKeratinocytesLocal Lymph Node AssayMiceMice, Inbred CBAMicroscopy, Electron, TransmissionNanoparticlesNeutral RedPolystyrenesRabbitsSkinTetrazolium SaltsThiazolesTitaniumToxicity Tests