The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2009
An expanded phenotype of maternal SSA/SSB antibody-associated fetal cardiac disease.
Клинический случайСтатьяПоддержка NIH: внешняя программаНазвание и аннотация: Перевод в очереди
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Cuneo Bettina F, Strasburger Janette F, Niksch Alisa, Ovadia Marc, Wakai Ronald T
Аннотация
OBJECTIVES: Conventional manifestations of fetal Sjogren's antibodies (SSA/SSB) associated cardiac disease include atrioventricular block (AVB), transient sinus bradycardia, endocardial fibroelastosis (EFE) and dilated cardiomyopathy. We describe other manifestations of cardiac disease.
METHODS: We describe three fetuses with unique myocardial and conduction system disease.
RESULTS: One had isolated EFE with subsequent mitral and tricuspid valve chordal avulsion, the second had sinoatrial and infrahissian conduction system disease, and in both, neonatal progression to life threatening disease occurred. The third had sinus node dysfunction and atrial flutter.
CONCLUSION: These findings expand the clinical phenotype of maternal SSA/SSB antibody associated fetal cardiac disease.
METHODS: We describe three fetuses with unique myocardial and conduction system disease.
RESULTS: One had isolated EFE with subsequent mitral and tricuspid valve chordal avulsion, the second had sinoatrial and infrahissian conduction system disease, and in both, neonatal progression to life threatening disease occurred. The third had sinus node dysfunction and atrial flutter.
CONCLUSION: These findings expand the clinical phenotype of maternal SSA/SSB antibody associated fetal cardiac disease.