Patch test results to the Spanish baseline patch test series according to age groups: A multicentric prospective study from 2019 to 2023.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
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Pesqué David, Planella-Fontanillas Nidia, Borrego Leopoldo, Sanz-Sánchez Tatiana, Zaragoza-Ninet Violeta, Serra-Baldrich Esther, Miquel-Miquel Francisco Javier, Silvestre-Salvador Juan Francisco, Córdoba-Guijarro Susana, Sánchez-Gilo Araceli, Mercader-García Pedro, Navarro-Triviño Francisco José, Ortiz-de-Frutos Francisco Javier, Tous-Romero Fátima, Rodríguez-Serna Mercedes, Melé-Ninot Gemma, Barrabés-Torrella Cristina, Ruiz-González Inmaculada, Pastor-Nieto María Antonia, Carrascosa-Carrillo José Manuel, Gómez-de-la-Fuente Enrique, Sánchez-Pedreño-Guillén Paloma, Sánchez-Pérez Javier, Pereyra-Rodríguez José Juan, Gatica-Ortega María Elena, González-Pérez Ricardo, Pujol Ramon Maria, Descalzo Miguel Ángel Gallego, García-Doval Ignacio, Giménez-Arnau Ana María
Аннотация
OBJECTIVES: We aim to evaluate the patch test results reflecting skin sensitisation, their relevance and association with clinical features by age group.
METHODS: Prospective multicentric study of all patients patch tested with the Spanish baseline series in participating centres. Age groups were pre-defined as children (0- to 11-years), adolescents (12- to 18-years), young adults (19- to 30-years), middle-aged adults (31- to 65-years) and older adults (≥66-years). Occurrence of sensitisation, relevance and clinical features were compared by age group. Factors associated with skin sensitisation were investigated with multivariate logistic regression.
RESULTS: A total of 13 368 patients were patch-tested. Differences in positive patch test results and relevance by age were detected with the highest proportion in middle-aged adults. Age-related trend differences were found for nickel, potassium dichromate, caines, colophony, Myroxylon pereirae resin, 2-hydroxyethyl methacrylate and limonene hydroperoxide. The multivariate logistic analysis (adjusted for sex, atopic dermatitis, body location and occupational dermatitis) showed an association between the age group of 31-65 (OR: 1.41, 95% CI: 1.26-1.58) and above 66-years (OR: 1.15, 95% CI: 1.01-1.32) with a higher proportion of positive results, compared with young adults.
CONCLUSIONS: Positive patch test results vary according to age, with the highest occurrence in middle-aged adults. Most haptens did not present age-related differences, reinforcing the use of baseline series regardless of age.