Pediatric transplantation · 2025
Toxoplasmosis Prophylaxis Practices: A Survey of International Pediatric Solid Organ Transplantation Centers.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод в очереди
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Hanisch Benjamin R, Ardura Monica I, Yildirim Inci, McCulloch Mignon, Michaels Marian G, Verma Anita
Аннотация
BACKGROUND: Toxoplasma gondii can cause opportunistic infections leading to life-threatening disseminated disease after organ transplantation. However, there is a paucity of pediatric-specific data to guide recommendations for the prevention of toxoplasmosis after solid organ transplantation.
METHODS: To assess current practices, international pediatric transplant providers were surveyed.
RESULTS: Considerable variability in both screening and prophylaxis strategies was found across centers and organ types, with heart transplant programs performing more screening and prophylaxis. Trimethoprim/sulfamethoxazole was the preferred prophylaxis agent for each graft; no toxoplasmosis cases were recalled while patients received prophylaxis.
CONCLUSION: More research is needed to clarify and standardize the optimal toxoplasmosis prevention strategy.
METHODS: To assess current practices, international pediatric transplant providers were surveyed.
RESULTS: Considerable variability in both screening and prophylaxis strategies was found across centers and organ types, with heart transplant programs performing more screening and prophylaxis. Trimethoprim/sulfamethoxazole was the preferred prophylaxis agent for each graft; no toxoplasmosis cases were recalled while patients received prophylaxis.
CONCLUSION: More research is needed to clarify and standardize the optimal toxoplasmosis prevention strategy.