American journal of dentistry · 2026
Clinical trial of essential oil-based dentifrices for denture cleaning and patient satisfaction.
СтатьяРандомизированное исследованиеНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Silva Arthur Am E, Clemente Lorena M, Ribeiro Adriana B, Oliveira Viviane D C, Macedo Ana P, Watanabe Evandro, Silva-Lovato Cláudia H
Аннотация
PURPOSE: This randomized, controlled, crossover, and triple-blind clinical trial evaluated the antibiofilm action and patient acceptance of four experimental dentifrices with essential oils at 1%.
METHODS: Participants (n= 24) selected based on eligibility criteria were randomly assigned to five groups: a positive control (chloramine T dentifrice), Melaleuca alternifolia (Ma), Pinus strobus (Ps), Bowdichia virgilioides Kunth (BvK), or Eucalyptus citriodora (Ec). They brushed their dentures three times/day with the provided brush and dentifrice for 14 days. A 7-day washout was established between each dentifrice use. Biofilm removal (computerized method), microbial load of Candida spp., Candida albicans, Candida tropicalis, Candida glabrata, Staphylococcus spp., Mutans streptococci, gram-negative bacteria, and total aerobes (colony-forming unit counting), cellular metabolism (XTT-assay), cell viability (flow cytometry), and patient satisfaction (questionnaire) were evaluated at baseline and after use of the dentifrices. Data were analyzed using Friedman's ANOVA and Cochran's Q Test for related samples (α= 0.05).
RESULTS: The amount of biofilm (P= 0.004) and the microbial load of C. albicans (P= 0.003) were significantly lower after the use of the dentifrices compared to baseline. The dentifrices did not significantly affect cell viability (P= 0.170) or cellular metabolism (P= 0.814). No significant differences in patient acceptance were found between the experimental dentifrices and the positive control. Experimental dentifrices with 1% Melaleuca alternifolia, Pinus strobus, Bowdichia virgilioides Kunth, and Eucalyptus citriodora effectively cleaned dentures, reduced C. albicans load, and were well accepted by users.
CLINICAL SIGNIFICANCE: Essential oil-based dentifrices effectively remove denture biofilm and reduce Candida albicans load, providing a natural and sustainable alternative to synthetic agents while being well accepted by users.
METHODS: Participants (n= 24) selected based on eligibility criteria were randomly assigned to five groups: a positive control (chloramine T dentifrice), Melaleuca alternifolia (Ma), Pinus strobus (Ps), Bowdichia virgilioides Kunth (BvK), or Eucalyptus citriodora (Ec). They brushed their dentures three times/day with the provided brush and dentifrice for 14 days. A 7-day washout was established between each dentifrice use. Biofilm removal (computerized method), microbial load of Candida spp., Candida albicans, Candida tropicalis, Candida glabrata, Staphylococcus spp., Mutans streptococci, gram-negative bacteria, and total aerobes (colony-forming unit counting), cellular metabolism (XTT-assay), cell viability (flow cytometry), and patient satisfaction (questionnaire) were evaluated at baseline and after use of the dentifrices. Data were analyzed using Friedman's ANOVA and Cochran's Q Test for related samples (α= 0.05).
RESULTS: The amount of biofilm (P= 0.004) and the microbial load of C. albicans (P= 0.003) were significantly lower after the use of the dentifrices compared to baseline. The dentifrices did not significantly affect cell viability (P= 0.170) or cellular metabolism (P= 0.814). No significant differences in patient acceptance were found between the experimental dentifrices and the positive control. Experimental dentifrices with 1% Melaleuca alternifolia, Pinus strobus, Bowdichia virgilioides Kunth, and Eucalyptus citriodora effectively cleaned dentures, reduced C. albicans load, and were well accepted by users.
CLINICAL SIGNIFICANCE: Essential oil-based dentifrices effectively remove denture biofilm and reduce Candida albicans load, providing a natural and sustainable alternative to synthetic agents while being well accepted by users.