Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2025
Dapsone 7.5% Gel Versus Trichloroacetic Acid Peels.
СтатьяСравнительное исследованиеНазвание и аннотация: Перевод в очереди
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Atallah Dalia A, Bestawy Sahar R, Abouelmajd Sara A, Badran Aya Y
Аннотация
BACKGROUND: Acne vulgaris is a chronic and multifactorial skin disease that can occur during adulthood, with a negative impact on self-esteem. Dapsone is a common antibacterial and anti-inflammatory medication used to treat several skin conditions.
OBJECTIVE: Objectives were to compare efficacy, tolerability, and safety of dapsone 7.5% gel versus trichloroacetic acid peel TCA 20% in the treatment of acne vulgaris.
MATERIALS AND METHODS: Thirty patients with acne vulgaris participated in a split-face, comparative, quasi-experimental clinical study. Trichloroacetic acid peels 20% were applied to the right side of the participants' face every 2 weeks for 3 months. The participants were instructed to apply dapsone 7.5% gel once daily at night on the left side of the face for 3 months.
RESULTS: There was a little difference between the 2 treatments; however, both sides of the face showed a considerable decrease in lesion counts and the Global Acne Grading Score (GAGS) after treatment.
CONCLUSION: The clinical effectiveness of trichloroacetic acid peeling and dapsone 7.5% gel was not significantly different in mild and moderate acne vulgaris. Dapsone 7.5% gel is more effective in treating inflammatory than noninflammatory lesions.
OBJECTIVE: Objectives were to compare efficacy, tolerability, and safety of dapsone 7.5% gel versus trichloroacetic acid peel TCA 20% in the treatment of acne vulgaris.
MATERIALS AND METHODS: Thirty patients with acne vulgaris participated in a split-face, comparative, quasi-experimental clinical study. Trichloroacetic acid peels 20% were applied to the right side of the participants' face every 2 weeks for 3 months. The participants were instructed to apply dapsone 7.5% gel once daily at night on the left side of the face for 3 months.
RESULTS: There was a little difference between the 2 treatments; however, both sides of the face showed a considerable decrease in lesion counts and the Global Acne Grading Score (GAGS) after treatment.
CONCLUSION: The clinical effectiveness of trichloroacetic acid peeling and dapsone 7.5% gel was not significantly different in mild and moderate acne vulgaris. Dapsone 7.5% gel is more effective in treating inflammatory than noninflammatory lesions.