Brain and behavior · 2025
Efficacy and Safety of Neuroendoscopy versus Craniotomy for Spontaneous Supratentorial Intracerebral Hemorrhage: An Updated Meta-Analysis of Randomized and Non-Randomized Studies.
Сравнительное исследованиеСтатьяМетаанализСистематический обзорНазвание и аннотация: Перевод в очереди
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Waseem Muhammad Hassan, Abideen Zain Ul, Rehman Nohela, Khan Muhammad Haris, Tahir Muhammad Fawad, Raja Hafsa Arshad Azam, Cheema Ameer Haider, Aimen Sania, Iqbal Javed
Аннотация
BACKGROUND: Spontaneous supratentorial intracerebral hemorrhage (ICH) is a critical condition with high morbidity and mortality rates warranting urgent surgical evacuation. This systematic review and meta-analysis compare the safety and efficacy of neuro-endoscopy (NE) versus traditional craniotomy (CR) for managing ICH.
METHODS: From inception until July 2024, a comprehensive literature search was undertaken on PubMed, Cochrane Central, ScienceDirect, and Clinicaltrials.gov. Risk ratios (RR) and weighted mean differences (WMD) were pooled for categorical and continuous outcomes under the random effects model in Review Manager software. 5.4.1. Leave-one-out sensitivity analysis, Egger's regression, GRADE assessment, and meta-regression were performed to evaluate the heterogeneity, publication bias, certainty of evidence, and effect size variability, respectively.
RESULTS: Our meta-analysis included eight clinical trials and 20 cohort studies with 9,437 patients. NE outperformed CR in terms of favorable neurological outcomes (RR = 1.59, 95% CI: [1.30,1.94]; p < 0.00001; I2 = 90%), mortality (RR = 0.62, 95% CI:[0.48,0.81]; p < 0.0004; I2 = 51%), hematoma evacuation rate (WMD = 7.17, 95% CI: [4.68,9.65]%; p < 0.00001; I 2 = 94%) operating time (WMD = -102.08 min, 95 CI: [-120.29,-83.87]; p < 0.00001; I2 = 98%), blood loss (WMD = -255.51 mL, 95% CI: [-383.61,-127.41]; p < 0.0001; I2 = 100%), length of hospital stay (WMD = -3.34 days, 95% CI: [-5.05,-1.64] days; p < 0.0001; I2 = 62%), ICU stay (WMD = -2.85, 95% CI: [-5.13,-0.57] days; p < 0.01; I2 = 96%), meningitis (RR = 0.58, 95% CI: [0.36,0.95]; p < 0.03; I2 = 10 %), infections (RR = 0.49, 95% CI: [0.35,0.67]; p < 0.0001; I2 = 51%), residual hematoma volume (MD = -2.22; 95% CI: [-3.37,-1.07]; p < 0.0002; I2 = 90%) and overall complications (RR = 0.52, 95% CI: [0.40-0.67]; p < 0.00001; I2 = 70%). In addition, re-bleeding was found to be comparable between the CR and NE groups (p = 0.08).
CONCLUSION: NE treatment for spontaneous intracerebral hemorrhage (ICH) is associated with favorable neurological outcomes, decreased mortality, shorter operating time, reduced blood loss and residual volume, shorter length of hospital and intensive care unit (ICU) stay, and fewer infections, meningitis, and overall complications; however, the re-bleeding rate was found to be comparable.
METHODS: From inception until July 2024, a comprehensive literature search was undertaken on PubMed, Cochrane Central, ScienceDirect, and Clinicaltrials.gov. Risk ratios (RR) and weighted mean differences (WMD) were pooled for categorical and continuous outcomes under the random effects model in Review Manager software. 5.4.1. Leave-one-out sensitivity analysis, Egger's regression, GRADE assessment, and meta-regression were performed to evaluate the heterogeneity, publication bias, certainty of evidence, and effect size variability, respectively.
RESULTS: Our meta-analysis included eight clinical trials and 20 cohort studies with 9,437 patients. NE outperformed CR in terms of favorable neurological outcomes (RR = 1.59, 95% CI: [1.30,1.94]; p < 0.00001; I2 = 90%), mortality (RR = 0.62, 95% CI:[0.48,0.81]; p < 0.0004; I2 = 51%), hematoma evacuation rate (WMD = 7.17, 95% CI: [4.68,9.65]%; p < 0.00001; I 2 = 94%) operating time (WMD = -102.08 min, 95 CI: [-120.29,-83.87]; p < 0.00001; I2 = 98%), blood loss (WMD = -255.51 mL, 95% CI: [-383.61,-127.41]; p < 0.0001; I2 = 100%), length of hospital stay (WMD = -3.34 days, 95% CI: [-5.05,-1.64] days; p < 0.0001; I2 = 62%), ICU stay (WMD = -2.85, 95% CI: [-5.13,-0.57] days; p < 0.01; I2 = 96%), meningitis (RR = 0.58, 95% CI: [0.36,0.95]; p < 0.03; I2 = 10 %), infections (RR = 0.49, 95% CI: [0.35,0.67]; p < 0.0001; I2 = 51%), residual hematoma volume (MD = -2.22; 95% CI: [-3.37,-1.07]; p < 0.0002; I2 = 90%) and overall complications (RR = 0.52, 95% CI: [0.40-0.67]; p < 0.00001; I2 = 70%). In addition, re-bleeding was found to be comparable between the CR and NE groups (p = 0.08).
CONCLUSION: NE treatment for spontaneous intracerebral hemorrhage (ICH) is associated with favorable neurological outcomes, decreased mortality, shorter operating time, reduced blood loss and residual volume, shorter length of hospital and intensive care unit (ICU) stay, and fewer infections, meningitis, and overall complications; however, the re-bleeding rate was found to be comparable.