[Sclerotic changes in the liver in experimental cholestasis and their reversibility following restoration of bile outflow].

A model of long-term cholestasis with the following recovery of intestinal bile outflow was developed on rats. In two experimental series choledochoduodenostomy was applied after 10- and 20-day cholestasis. It was established that in 10-day cholestasis perilobular hepatic fibrosis developed and bile outflow recovery in this period caused complete normalization of the liver structure a month later. 20-day cholestasis produced absolute parenchymal and stromal disorganization and the onset of biliary liver cirrhosis. Bile outflow recovery in such animals normalized only parenchymal, but not stromal structure; sclerotic processes were seldom reversed. Thus, the above cholestasis model precipitates the onset of liver cirrhosis and the technique of intestinal bile outflow recovery makes it possible to study the reversibility of pathologic hepatic changes.