Medicine · 2025
Low-grade appendiceal mucinous neoplasm associated with ulcerative colitis: A case report and literature review.
СтатьяКлинический случайОбзорНазвание и аннотация: Перевод в очереди
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Muto Yasuhide, Hara Hitoshi, Shimizu Seito, Kido Tomoki, Miyata Ryohei, Itabashi Michio
Аннотация
RATIONALE: Colorectal cancer (CRC) development is a critical prognostic factor for patients with ulcerative colitis (UC), making its early detection important. However, early detection of CRC is clinically challenging. This case report describes a patient diagnosed with transverse colon cancer and a low-grade appendiceal mucinous neoplasm (LAMN) in the context of pancolitis-type UC.
PATIENT CONCERNS: A 59-year-old male patient with a 24-year history of pancolitis-type UC was referred to our hospital after a routine surveillance colonoscopy for the first time in 5 years revealed transverse colon cancer.
DIAGNOSES: Colonoscopy revealed type 3 advanced carcinoma in the transverse colon and a protruding lesion resembling a laterally spreading granular tumor at the appendiceal orifice. Computed tomography demonstrated enlargement of the appendix.
INTERVENTIONS: The patient underwent laparoscopic total colectomy, lymph node dissection of transverse colon cancer, ileal pouch-anal anastomosis, and temporary ileostomy.
OUTCOMES: The patient was diagnosed with stage IIA transverse colon cancer. Additionally, the appendiceal lesion was diagnosed as a LAMN, a relatively novel pathological entity considered a precursor to appendiceal mucinous adenocarcinoma.
LESSONS: Although the appendix is part of the colon and can serve as a site for UC-CRC development in patients with pancolitis-type UC, identifying appendiceal lesions through routine surveillance comprising colonoscopy alone may be challenging. In patients with pancolitis-type UC, lesions known as LAMN, which are recognized as precursors of appendiceal mucinous adenocarcinoma, may develop, thereby requiring careful monitoring.
PATIENT CONCERNS: A 59-year-old male patient with a 24-year history of pancolitis-type UC was referred to our hospital after a routine surveillance colonoscopy for the first time in 5 years revealed transverse colon cancer.
DIAGNOSES: Colonoscopy revealed type 3 advanced carcinoma in the transverse colon and a protruding lesion resembling a laterally spreading granular tumor at the appendiceal orifice. Computed tomography demonstrated enlargement of the appendix.
INTERVENTIONS: The patient underwent laparoscopic total colectomy, lymph node dissection of transverse colon cancer, ileal pouch-anal anastomosis, and temporary ileostomy.
OUTCOMES: The patient was diagnosed with stage IIA transverse colon cancer. Additionally, the appendiceal lesion was diagnosed as a LAMN, a relatively novel pathological entity considered a precursor to appendiceal mucinous adenocarcinoma.
LESSONS: Although the appendix is part of the colon and can serve as a site for UC-CRC development in patients with pancolitis-type UC, identifying appendiceal lesions through routine surveillance comprising colonoscopy alone may be challenging. In patients with pancolitis-type UC, lesions known as LAMN, which are recognized as precursors of appendiceal mucinous adenocarcinoma, may develop, thereby requiring careful monitoring.