PLoS neglected tropical diseases · 2026
Anthrax outbreak associated with the consumption and handling of carcasses of livestock that suddenly died, Kanungu District, Uganda, June-November 2024.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Mutesi Charity, Migisha Richard, Katumba Hannington, Ainembabazi Bridget, Naiga Helen Nelly, Kellermann Scott, Mutahunga Birungi, Ouma Fred, Tumwesigye Aloysius, Ilimaso Frank, Bulage Lilian, Ario Alex Riolexus
Аннотация
BACKGROUND: Anthrax is a recurrent zoonosis in Uganda, with 11 outbreaks reported in 2024. On September 17, 2024, the Ministry of Health received reports of two human deaths in Kanungu District, later confirmed as anthrax-the district's first recorded outbreak. We investigated to determine its scope, risk factors, and recommend control measures.
METHODS: We defined a suspected cutaneous anthrax case as an acute onset of skin lesions (papule, vesicle, or eschar) with ≥2 of itching, reddening, lymphadenopathy, fever, or malaise. Suspected gastrointestinal anthrax was onset of abdominal pain with ≥2 of vomiting, diarrhea, fever, or loss of appetite in a Kanungu resident from June-November 2024. Confirmation required Polymerase Chain Reaction (PCR) detection of Bacillus anthracis. In a 1:2 unmatched case-control study, we enrolled all cases and controls from neighboring asymptomatic households in the two most affected sub-counties. Logistic regression was used to identify risk factors for infection.
RESULTS: We identified 90 cases (86 suspected and 4 confirmed); 80% had cutaneous, 11% gastrointestinal, and 9% both forms. Males were more affected (attack rate [AR]=48/100,000) than females (AR = 15/100,000); case fatality rate was 6.7% (6/90). Overall, 10/27 sub-counties were affected, with Bugongi (AR = 257/100,000) being the most affected. Consuming meat from suddenly dead livestock (adjusted odds ratio [aOR]=5.5, 95% CI: 2.7-11), handling carcasses (aOR=8.2, 95% CI: 3.8-18), having a low education level (aOR=6.0, 95% CI: 2.6-14), and being male (aOR=2.3, 95%CI = 1.03-4.9) increased the odds of infection. Notably, 90% of the case-patients purchased the contaminated meat from a single dealer.
CONCLUSION: The outbreak was linked to consuming and handling meat from livestock that died suddenly, underscoring gaps in veterinary inspection and carcass management. Strengthening inspections, enforcing carcass disposal, and targeted community education are essential for prevention.
METHODS: We defined a suspected cutaneous anthrax case as an acute onset of skin lesions (papule, vesicle, or eschar) with ≥2 of itching, reddening, lymphadenopathy, fever, or malaise. Suspected gastrointestinal anthrax was onset of abdominal pain with ≥2 of vomiting, diarrhea, fever, or loss of appetite in a Kanungu resident from June-November 2024. Confirmation required Polymerase Chain Reaction (PCR) detection of Bacillus anthracis. In a 1:2 unmatched case-control study, we enrolled all cases and controls from neighboring asymptomatic households in the two most affected sub-counties. Logistic regression was used to identify risk factors for infection.
RESULTS: We identified 90 cases (86 suspected and 4 confirmed); 80% had cutaneous, 11% gastrointestinal, and 9% both forms. Males were more affected (attack rate [AR]=48/100,000) than females (AR = 15/100,000); case fatality rate was 6.7% (6/90). Overall, 10/27 sub-counties were affected, with Bugongi (AR = 257/100,000) being the most affected. Consuming meat from suddenly dead livestock (adjusted odds ratio [aOR]=5.5, 95% CI: 2.7-11), handling carcasses (aOR=8.2, 95% CI: 3.8-18), having a low education level (aOR=6.0, 95% CI: 2.6-14), and being male (aOR=2.3, 95%CI = 1.03-4.9) increased the odds of infection. Notably, 90% of the case-patients purchased the contaminated meat from a single dealer.
CONCLUSION: The outbreak was linked to consuming and handling meat from livestock that died suddenly, underscoring gaps in veterinary inspection and carcass management. Strengthening inspections, enforcing carcass disposal, and targeted community education are essential for prevention.